Gene
shox2
- ID
- ZDB-GENE-040426-1457
- Name
- shox homeobox 2
- Symbol
- shox2 Nomenclature History
- Previous Names
-
- zgc:65884
- zgc:77344
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within heart development and regulation of heart contraction. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge pectoral fin bud; heart; nervous system; otic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human SHOX2 (SHOX homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77344 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired homeobox Bicoid subfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QLB7
|
233 | ||||||
|
UniProtKB:A0A8M9Q089
|
221 | ||||||
|
UniProtKB:A0A8M9QPS7
|
287 | ||||||
|
UniProtKB:Q7SZN8
|
299 |
Interactions and Pathways
No data available
Plasmids
No data available