Gene
ildr1a
- ID
- ZDB-GENE-040426-1412
- Name
- immunoglobulin-like domain containing receptor 1a
- Symbol
- ildr1a Nomenclature History
- Previous Names
-
- zgc:64227
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Is expressed in EVL; ectoderm; and sensory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 42. Orthologous to human ILDR1 (immunoglobulin like domain containing receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64227 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ildr1a | (2) | |
| CRISPR2-ildr1a | Varshney et al., 2015 | |
| CRISPR3-ildr1a | (2) | |
| MO1-ildr1a | N/A | Sang et al., 2014 |
| MO2-ildr1a | N/A | Sang et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 42 | Alliance | Deafness, autosomal recessive 42 | 609646 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
ildr1a-202
(1)
|
Ensembl | 618 nt | ||
| mRNA |
ildr1a-205
(1)
|
Ensembl | 2,623 nt | ||
| mRNA |
ildr1a-206
(1)
|
Ensembl | 917 nt | ||
| ncRNA |
ildr1a-002
(1)
|
Ensembl | 389 nt | ||
| ncRNA |
ildr1a-005
(1)
|
Ensembl | 632 nt | ||
| ncRNA |
ildr1a-006
(1)
|
Ensembl | 402 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1011F11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64227 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200393 (1) | 2267 nt | ||
| Genomic | GenBank:FP475876 (1) | 37557 nt | ||
| Polypeptide | RefSeq:NP_956687 (1) |
- Gasanov, E.V., Jędrychowska, J., Kuźnicki, J., Korzh, V. (2021) Evolutionary context can clarify gene names: Teleosts as a case study. BioEssays : news and reviews in molecular, cellular and developmental biology. 43(6):e2000258
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Sang, Q., Zhang, J., Feng, R., Wang, X., Li, Q., Zhao, X., Xing, Q., Chen, W., Du, J., Sun, S., Chai, R., Jin, L., He, L., Li, H., Wang, L. (2014) Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium, and hearing ability in zebrafish: Implications for a role in the recessive hearing impairment DFNB42. Human molecular genetics. 23(23):6201-11
- Borck, G., Rehman, A.U., Lee, K., Pogoda, H.M., Kakar, N., von Ameln, S., Grillet, N., Hildebrand, M.S., Ahmed, Z.M., Nürnberg, G., Ansar, M., Basit, S., Javed, Q., Morell, R.J., Nasreen, N., Shearer, A.E., Ahmad, A., Kahrizi, K., Shaikh, R.S., Ali, R.A., Khan, S.N., Goebel, I., Meyer, N.C., Kimberling, W.J., Webster, J.A., Stephan, D.A., Schiller, M.R., Bahlo, M., Najmabadi, H., Gillespie, P.G., Nürnberg, P., Wollnik, B., Riazuddin, S., Smith, R.J., Ahmad, W., Müller, U., Hammerschmidt, M., Friedman, T.B., Riazuddin, S., Leal, S.M., Ahmad, J., and Kubisch, C. (2011) Loss-of-Function Mutations of ILDR1 Cause Autosomal-Recessive Hearing Impairment DFNB42. American journal of human genetics. 88(2):127-137
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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