Gene
spop
- ID
- ZDB-GENE-040426-1378
- Name
- speckle type BTB/POZ protein
- Symbol
- spop Nomenclature History
- Previous Names
-
- zgc:64140
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in nuclear speck. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64140 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Boysen et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-spop | (2) | |
| MO1-spop | N/A | Boysen et al., 2015 |
| MO2-spop | N/A | Boysen et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | MATH/TRAF domain | SKP1/BTB/POZ domain superfamily | SPOP, C-terminal BACK domain | TRAF-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T330 | InterPro | 374 | |||||
| UniProtKB:A7YYH8 | InterPro | 374 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-348M5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-152J7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-213I9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-66B12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64140 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174052 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201130 (1) | 2813 nt | ||
| Genomic | GenBank:BX248239 (2) | 200856 nt | ||
| Polypeptide | UniProtKB:A7YYH8 (1) | 374 aa |
- Yu, G.Q., Chen, M.J., Wang, Y.J., Liu, Y.Q., Zuo, M.Z., Zhang, Z.H., Li, G.X., Liu, B.Z., Li, M. (2023) Zebrafish spop promotes ubiquitination and degradation of mavs to suppress antiviral response via the lysosomal pathway. International journal of biological macromolecules. 256(Pt 2):128451
- Gistelinck, C., Gioia, R., Gagliardi, A., Tonelli, F., Marchese, L., Bianchi, L., Landi, C., Bini, L., Huysseune, A., Witten, P.E., Staes, A., Gevaert, K., De Rocker, N., Menten, B., Malfait, F., Leikin, S., Carra, S., Tenni, R., Rossi, A., De Paepe, A., Coucke, P., Willaert, A., Forlino, A. (2016) Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Scientific Reports. 6:21540
- Boysen, G., Barbieri, C.E., Prandi, D., Blattner, M., Chae, S.S., Dahija, A., Nataraj, S., Huang, D., Marotz, C., Xu, L., Huang, J., Lecca, P., Chhangawala, S., Liu, D., Zhou, P., Sboner, A., de Bono, J.S., Demichelis, F., Houvras, Y., Rubin, M.A. (2015) SPOP mutation leads to genomic instability in prostate cancer. eLIFE. 4
- Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., Schier, A.F. (2014) Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs. PLoS One. 9:e98186
- Kok, F.O., Taibi, A., Wanner, S.J., Xie, X., Moravec, C.E., Love, C.E., Prince, V.E., Mumm, J.S., and Sirotkin, H.I. (2012) Zebrafish rest regulates developmental gene expression but not neurogenesis. Development (Cambridge, England). 139(20):3838-3848
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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