Gene
grinab
- ID
- ZDB-GENE-040426-1367
- Name
- glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding)
- Symbol
- grinab Nomenclature History
- Previous Names
-
- grina
- tmbim3 (1)
- zgc:64102
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within negative regulation of apoptotic process and negative regulation of neuron death. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in eye; head; nervous system; and spinal cord. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64102 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Rojas-Rivera et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR006214 | Bax inhibitor 1-related |
1 - 1 of 1
Domain Details Per Protein
Protein | Length | Bax inhibitor 1-related |
---|---|---|
UniProtKB:A0A8M2B4U7
|
337 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
grinab-201
(1)
|
Ensembl | 1,657 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-214L23 | ZFIN Curated Data | |
Contained in | BAC | DKEY-199L17 | ZFIN Curated Data | |
Encodes | cDNA | MGC:64102 | ZFIN Curated Data | |
Encodes | cDNA | MGC:174823 | ZFIN Curated Data |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001308611 (1) | 1648 nt | ||
Genomic | GenBank:CR759845 (1) | 181187 nt | ||
Polypeptide | UniProtKB:A0A8M2B4U7 (1) | 337 aa |
- Chen, K., Li, X., Song, G., Zhou, T., Long, Y., Li, Q., Zhong, S., Cui, Z. (2019) Deficiency in the membrane protein Tmbim3a/Grinaa initiates cold-induced ER stress and cell death by activating an intrinsic apoptotic pathway in zebrafish. The Journal of biological chemistry. 294(30):11445-11457
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Rojas-Rivera, D., Armisén, R., Colombo, A., Martínez, G., Eguiguren, A.L., Díaz, A., Kiviluoto, S., Rodríguez, D., Patron, M., Rizzuto, R., Bultynck, G., Concha, M.L., Sierralta, J., Stutzin, A., and Hetz, C. (2012) TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell death and differentiation. 19(6):1013-1026
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 4 of 4
Show