Gene

c6.1

ID

ZDB-GENE-040426-1358

Name

complement component 6, duplicate 1

Symbol

c6.1 Nomenclature History

Previous Names

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to be involved in complement activation. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Is expressed in epidermis; gut; liver; periderm; and pharyngeal arch 3-7 skeleton. Orthologous to human C6 (complement C6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64073 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c6.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
complement component 6 deficiency	Alliance	C6 deficiency	612446

Associated With c6.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020863	Membrane attack complex component/perforin domain, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR003884	Factor I / membrane attack complex
Domain	IPR020864	Membrane attack complex component/perforin (MACPF) domain
Domain	IPR048828	Complement component C6, KAZAL domain
Domain	IPR048831	Complement components C8A/B/C6, EGF-like domain
Family	IPR001862	Membrane attack complex component/perforin/complement C9
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Complement component C6, KAZAL domain	Complement components C8A/B/C6, EGF-like domain	Factor I / membrane attack complex	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Membrane attack complex component/perforin/complement C9	Membrane attack complex component/perforin domain, conserved site	Membrane attack complex component/perforin (MACPF) domain	Sushi/SCR/CCP domain	Sushi/SCR/CCP superfamily	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M2B830 InterPro	840
UniProtKB:Q6PFT2 InterPro	885
UniProtKB:A0A8M2B846 InterPro	905
UniProtKB:A0A8M9Q791 InterPro	840
UniProtKB:A0A8M6Z3V5 InterPro	790
UniProtKB:A0A8M9PDC6 InterPro	718
UniProtKB:A0A8M9PIV7 InterPro	642

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	c6-208 (1) Ensembl	Ensembl	3,002 nt	Select Tool
mRNA	c6-209 (1) Ensembl	Ensembl	834 nt	Select Tool
mRNA	c6-210 (1) Ensembl	Ensembl	2,565 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations