Gene

c6

ID
ZDB-GENE-040426-1358
Name
complement component 6
Symbol
c6 Nomenclature History
Previous Names
  • zgc:64073
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to be involved in complement activation, classical pathway; cytolysis; and innate immune response. Predicted to localize to extracellular region and membrane attack complex. Is expressed in epidermis; gut; liver; periderm; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
complement component 6 deficiency Alliance C6 deficiency 612446
Combined C6/C7 deficiency
Associated With c6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR003884 Factor I / membrane attack complex
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Family IPR001862 Membrane attack complex component/perforin/complement C9
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Factor I / membrane attack complex LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Membrane attack complex component/perforin/complement C9 Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:E9QGS7 243
UniProtKB:Q6PFT2 885
UniProtKB:A0A2R8Q5A9 899
UniProtKB:A0A0B5JFE1 280
UniProtKB:F1Q611 855
UniProtKB:E9QB99 907
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations