Gene

prkacba

ID

ZDB-GENE-040426-1351

Name

protein kinase, cAMP-dependent, catalytic, beta a

Symbol

prkacba Nomenclature History

Previous Names

zgc:64054

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable cAMP-dependent protein kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; fin bud; hatching gland; optic cup; and retinal neural layer. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Emerson et al., 2018

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkacba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cardioacrofacial dysplasia 2	619143

Associated With prkacba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Family	IPR044109	cAMP-dependent protein kinase catalytic subunit
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily