Gene

myo1eb

ID

ZDB-GENE-040426-1347

Name

myosin IEb

Symbol

myo1eb Nomenclature History

Previous Names

zgc:64042

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Is expressed in several structures, including EVL; ectoderm; epidermis; peripheral olfactory organ; and pharynx. Orthologous to human MYO1E (myosin IE).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64042 (22 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo1eb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
focal segmental glomerulosclerosis 6	Alliance	Glomerulosclerosis, focal segmental, 6	614131

Associated With myo1eb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR010926	Class I myosin tail homology domain
Domain	IPR035507	Unconventional myosin-Ie/If, SH3 domain
Domain	IPR036072	Class I myosin, motor domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily