Gene

ucp3

ID

ZDB-GENE-040426-1317

Name

uncoupling protein 3

Symbol

ucp3 Nomenclature History

Previous Names

ucp2l
zgc:63967

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to localize to integral component of membrane and mitochondrial membrane. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Is expressed in several structures, including brain; eye; heart; integument; and pleuroperitoneal region. Orthologous to human UCP3 (uncoupling protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63967 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ucp3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
obesity	Alliance	{Obesity, severe, and type II diabetes}	601665

Associated With ucp3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002067	Mitochondrial carrier protein
Family	IPR050391	Mitochondrial Metabolite Transporter
Homologous_superfamily	IPR023395	Mitochondrial carrier domain superfamily
Repeat	IPR018108	Mitochondrial substrate/solute carrier