Gene

gnai1

ID

ZDB-GENE-040426-1310

Name

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Symbol

gnai1 Nomenclature History

Previous Names

Galpha i1a (1)
zgc:63957

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Is expressed in barbel; brain; gill; lip; and sensory system. Orthologous to human GNAI1 (G protein subunit alpha i1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnai1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	619854

Associated With gnai1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
Family	IPR001408	G-protein alpha subunit, group I
Homologous_superfamily	IPR011025	G protein alpha subunit, helical insertion
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase