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ZIRC
ZFIN ID: ZDB-GENE-040426-1303
Gene Name: diablo, IAP-binding mitochondrial protein a
Gene Symbol: diabloa    Nomenclature History

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Previous Names: diablo, smac (1), zgc:63938

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; intrinsic apoptotic signaling pathway in response to oxidative stress; and neuron apoptotic process. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 64. Is expressed in several structures, including cardiovascular system; digestive system; lens; pectoral fin; and solid lens vesicle. Orthologous to human DIABLO (diablo IAP-binding mitochondrial protein).
Genome Resources: Alliance (1),  Gene:393317 (1),  Ensembl(GRCz11):ENSDARG00000104172 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:7162253]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH diabloa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 64 Alliance Deafness, autosomal dominant 64 614152
DISEASE ASSOCIATED WITH diabloa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process (more)
Cellular Component mitochondrion (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009062 (1)
  • InterPro:IPR015142 (1)
  • Pfam:PF09057 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA diabloa-202 (1)    Ensembl 1478
    diabloa-204 (1)    Ensembl 895
    ncRNA diabloa-002 (1)    Ensembl 791
    diabloa-003 (1)    Ensembl 887
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM diabloa No data available
    MARKER RELATIONSHIPS
    diabloa Contained in: [BAC] CH211-24O8 (1) (order this)
    diabloa Encodes: [EST] IMAGE:7162253 (1) (order this)
    [cDNA] MGC:63938 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200346 (1) 1275 bp
    Genomic GenBank:CR936977 (1) 187860 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IUC3 (1) 265 aa
    Sequence Clusters UniGene:18420 (1)
    Sequence Information (all 12)
    ORTHOLOGY for diabloa ( Chr: 15 )
    CITATIONS (20)