Gene

ap4b1

ID

ZDB-GENE-040426-1284

Name

adaptor related protein complex 4 subunit beta 1

Symbol

ap4b1 Nomenclature History

Previous Names

ap4b1l
zgc:63878 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable clathrin binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in endomembrane system and membrane. Predicted to be part of clathrin adaptor complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 47. Orthologous to human AP4B1 (adaptor related protein complex 4 subunit beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63878 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ap4b1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 47	Alliance	Spastic paraplegia 47, autosomal recessive	614066

Associated With ap4b1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
Domain	IPR015151	Beta-adaptin appendage, C-terminal subdomain
Family	IPR016342	AP-1/2/4 complex subunit beta
Family	IPR026739	AP complex subunit beta
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR012295	TBP domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold