ZFIN ID: ZDB-GENE-040426-1282
Gene Name: SIX homeobox 6a
Gene Symbol: six6a    Nomenclature History

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Previous Name: zgc:63871

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in neural retina development. Predicted to localize to nucleus and transcription regulator complex. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6).
Genome Resources: Alliance (1),  Gene:394080 (1),  Ensembl(GRCz11):ENSDARG00000025187 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ja62 Small Deletion Unknown Unknown TALEN
sa16265 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa18444 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31940 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-six6a N/A 2
    MO2-six6a N/A 1
    TALEN1-six6a 1
    DISEASE ASSOCIATED WITH six6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    optic disc anomalies with retinal and/or macular dystrophy Alliance Optic disc anomalies with retinal and/or macular dystrophy 212550
    DISEASE ASSOCIATED WITH six6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural retina development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA six6a-201 (1)    Ensembl 1255
    six6a-202 (1)    Ensembl 974
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM six6a No data available
    MARKER RELATIONSHIPS
    six6a Contained in: [BAC] CH211-202M24 (1)
    six6a Encodes: [cDNA] MGC:63871 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201105 (1) 1317 nt
    Genomic GenBank:BX537123 (1) 202967 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q7T3G8 (1) 245 aa
    Sequence Information (all 9)
    ORTHOLOGY for six6a ( Chr: 13 )
    CITATIONS (29)