Gene
six6a
- ID
- ZDB-GENE-040426-1282
- Name
- SIX homeobox 6a
- Symbol
- six6a Nomenclature History
- Previous Names
-
- zgc:63871
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within gene expression and neural retina development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including eye; heart; integument; kidney; and telencephalon. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| optic disc anomalies with retinal and/or macular dystrophy | Alliance | Optic disc anomalies with retinal and/or macular dystrophy | 212550 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox protein SIX1, N-terminal SD domain | Homeodomain |
|---|---|---|---|---|---|
| UniProtKB:Q7T3G8 | InterPro | 245 | |||
| UniProtKB:A0AB32T4G5 | InterPro | 283 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available