Gene

ddb1

ID

ZDB-GENE-040426-1272

Name

damage-specific DNA binding protein 1

Symbol

ddb1 Nomenclature History

Previous Names

zgc:63840

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable nucleic acid binding activity. Acts upstream of or within negative regulation of apoptotic process and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be active in nucleus and site of double-strand break. Is expressed in blastomere; endoderm; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in communication disorder. Orthologous to human DDB1 (damage specific DNA binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Hu et al., 2015

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		White-Kernohan syndrome	619426

Associated With ddb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Domain	IPR018846	RSE1/DDB1/CPSF1, first beta-propeller domain
Family	IPR050358	RSE1/DDB1/CFT1/CPSF1
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily