Gene
nt5e
- ID
- ZDB-GENE-040426-1261
- Name
- 5'-nucleotidase, ecto (CD73)
- Symbol
- nt5e Nomenclature History
- Previous Names
-
- zgc:63784
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable 5'-nucleotidase activity. Acts upstream of or within response to copper ion. Predicted to be active in plasma membrane. Is expressed in brain and intestinal bulb. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63784 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary arterial and articular multiple calcification syndrome | Alliance | Calcification of joints and arteries | 211800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006146 | 5'-Nucleotidase, conserved site |
| Domain | IPR008334 | 5'-Nucleotidase, C-terminal |
| Family | IPR006179 | 5'-Nucleotidase/apyrase |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
| Homologous_superfamily | IPR036907 | 5'-Nucleotidase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 5'-Nucleotidase/apyrase | 5'-Nucleotidase, conserved site | 5'-Nucleotidase, C-terminal | 5'-Nucleotidase, C-terminal domain superfamily | Metallo-dependent phosphatase-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXU4 | InterPro | 571 | |||||
| UniProtKB:A0A8M1PBZ9 | InterPro | 570 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available