Gene
nt5e
- ID
- ZDB-GENE-040426-1261
- Name
- 5'-nucleotidase, ecto (CD73)
- Symbol
- nt5e Nomenclature History
- Previous Names
-
- zgc:63784
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable 5'-nucleotidase activity. Acts upstream of or within response to copper ion. Predicted to be active in plasma membrane. Is expressed in brain and intestinal bulb. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63784 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028295Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8734 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary arterial and articular multiple calcification syndrome | Alliance | Calcification of joints and arteries | 211800 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006146 | 5'-Nucleotidase, conserved site |
| Domain | IPR008334 | 5'-Nucleotidase, C-terminal |
| Family | IPR006179 | 5'-Nucleotidase/apyrase |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
| Homologous_superfamily | IPR036907 | 5'-Nucleotidase, C-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | 5'-Nucleotidase/apyrase | 5'-Nucleotidase, conserved site | 5'-Nucleotidase, C-terminal | 5'-Nucleotidase, C-terminal domain superfamily | Metallo-dependent phosphatase-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXU4 | InterPro | 571 | |||||
| UniProtKB:A0A8M1PBZ9 | InterPro | 570 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-241P10 | ||
| Encodes | cDNA | MGC:63784 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200932 (1) | 2257 nt | ||
| Genomic | GenBank:BX537259 (1) | 185460 nt | ||
| Polypeptide | UniProtKB:Q7SXU4 (1) | 571 aa |
- Nazario, L.R., de Sousa, J.S., de Moraes Silveira, F.S., Costa, K.M., de Oliveira, G.M.T., Bogo, M.R., da Silva, R.S. (2022) Participation of ecto-5'-nucleotidase in the inflammatory response in an adult zebrafish (Danio rerio) model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 260:109402
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Cruz, F.F., Pereira, T.C.B., Altenhofen, S., da Costa, K.M., Bogo, M.R., Bonan, C.D., Morrone, F.B. (2019) Characterization of the adenosinergic system in a zebrafish embryo radiotherapy model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 224:108572
- Lutte, A.H., Nazario, L.R., Majolo, J.H., Pereira, T.C.B., Altenhofen, S., da Silva Dadda, A., Bogo, M.R., Da Silva, R.S. (2018) Persistent increase in ecto‑5'‑nucleotidase activity from encephala of adult zebrafish exposed to ethanol during early development. Neurotoxicology and teratology. 70:60-66
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wakisaka, N., Miyasaka, N., Koide, T., Masuda, M., Hiraki-Kajiyama, T., Yoshihara, Y. (2017) An Adenosine Receptor for Olfaction in Fish. Current biology : CB. 27(10):1437-1447.e4
- Zimmermann, F.F., Gaspary, K.V., Siebel, A.M., Leite, C.E., Kist, L.W., Bogo, M.R., Bonan, C.D. (2017) Analysis of Extracellular Nucleotide Metabolism in Adult Zebrafish After Embryological Exposure to Valproic Acid. Molecular neurobiology. 54(5):3542-3553
- Capiotti, K.M., Siebel, A.M., Kist, L.W., Bogo, M.R., Bonan, C.D., Da Silva, R.S. (2016) Hyperglycemia alters E-NTPDases, ecto-5'-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio). Purinergic signalling. 12(2):211-20
- Vuaden, F.C., Savio, L.E., Rico, E.P., Mussulini, B.H., Rosemberg, D.B., de Oliveira, D.L., Bogo, M.R., Bonan, C.D., Wyse, A.T. (2016) Methionine Exposure Alters Glutamate Uptake and Adenine Nucleotide Hydrolysis in the Zebrafish Brain. Molecular neurobiology. 53(1):200-9
- Altenhofen, S., Zimmermann, F.F., Barreto, L.S., Bortolotto, J.W., Kist, L.W., Bogo, M.R., Bonan, C.D. (2015) Benzodiazepines alter nucleotide and nucleoside hydrolysis in zebrafish (Danio rerio) brain. Journal of neural transmission (Vienna, Austria : 1996). 122(8):1077-88
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