Gene
rars2
- ID
- ZDB-GENE-040426-1244
- Name
- arginyl-tRNA synthetase 2, mitochondrial
- Symbol
- rars2 Nomenclature History
- Previous Names
-
- zgc:63702
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable arginine-tRNA ligase activity. Acts upstream of or within brain morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63702 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kasher et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pontocerebellar hypoplasia type 6 | Alliance | Pontocerebellar hypoplasia, type 6 | 611523 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR008909 | DALR anticodon binding |
| Domain | IPR035684 | Arginyl-tRNA synthetase, catalytic core domain |
| Family | IPR001278 | Arginine-tRNA ligase |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Arginine-tRNA ligase | Arginyl-tRNA synthetase, catalytic core domain | DALR anticodon binding | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PGW8
|
597 | ||||||
|
UniProtKB:A0A8M3AVZ0
|
577 |
Interactions and Pathways
No data available
Plasmids
No data available