Gene

xrn1

ID

ZDB-GENE-040426-1203

Name

5'-3' exoribonuclease 1

Symbol

xrn1 Nomenclature History

Previous Names

wu:fk92c07
zgc:63635

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have 5'-3' exonuclease activity and RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63635 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xrn1 Human Ortholog

No data available

Associated With xrn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004859	Xrn1, N-terminal
Domain	IPR040992	5'-3' exoribonuclease 1, D1 domain
Domain	IPR041106	Exoribonuclease Xrn1, D2/D3 domain
Domain	IPR041385	5'-3' exoribonuclease 1, SH3-like domain
Domain	IPR041412	Xrn1, helical domain
Family	IPR016494	5'-3' exoribonuclease 1
Family	IPR027073	5'-3' exoribonuclease
Homologous_superfamily	IPR047007	5'-3' exoribonuclease 1, D1 domain superfamily
Homologous_superfamily	IPR047008	5'-3' exoribonuclease 1, SH3-like domain superfamily