Gene
cyp46a1.2
- ID
- ZDB-GENE-040426-1184
- Name
- cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 2
- Symbol
- cyp46a1.2 Nomenclature History
- Previous Names
-
- cyp46a2
- zgc:63602
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have cholesterol 24-hydroxylase activity; heme binding activity; and iron ion binding activity. Predicted to be involved in cholesterol catabolic process and oxidation-reduction process. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in blood and intermediate cell mass of mesoderm. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63602 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cholesterol 24-hydroxylase | Cytochrome P450 | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7SY18
|
444 | ||||
|
UniProtKB:A0A8M3AW06
|
501 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp46a1.2-201
(1)
|
Ensembl | 1,829 nt |
Interactions and Pathways
No data available
Plasmids
No data available