Gene
aldh4a1
- ID
- ZDB-GENE-040426-1179
- Name
- aldehyde dehydrogenase 4 family, member A1
- Symbol
- aldh4a1 Nomenclature History
- Previous Names
-
- zgc:63592
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to act upstream of or within proline metabolic process. Predicted to be located in mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; optic tectum; optic vesicle; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63592 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyperprolinemia type 2 | Alliance | Hyperprolinemia, type II | 239510 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Family | IPR005931 | Delta-1-pyrroline-5-carboxylate dehydrogenase |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
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Domain Details Per Protein
| Protein | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase | Delta-1-pyrroline-5-carboxylate dehydrogenase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SY23
|
556 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh4a1-201
(1)
|
Ensembl | 1,954 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-347B24 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-1132D4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63592 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201158 (1) | 1985 nt | ||
| Genomic | GenBank:CU633737 (1) | 27522 nt | ||
| Polypeptide | UniProtKB:Q7SY23 (1) | 556 aa |
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J.H., Patton, E.E. (2022) Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development (Cambridge, England). 149(10):
- Yan, Y., Xu, Y., Yang, X., Li, Z., Niu, K., Liu, C., Zhao, M., Xiao, Q., Wu, W. (2022) Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption. Oxidative medicine and cellular longevity. 2022:7969916
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Zhao, T., Ye, S., Tang, Z., Guo, L., Ma, Z., Zhang, Y., Yang, C., Peng, J., Chen, J. (2021) Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish. Cell Death & Disease. 12:151
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Ye, S., Zhao, T., Zhang, W., Tang, Z., Gao, C., Ma, Z., Xiong, J.W., Peng, J., Tan, W.Q., Chen, J. (2020) p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Cell Death & Disease. 11:568
- Park, J., Belden, W.J. (2018) Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin. BMC Genomics. 19:777
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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