Gene

aldh4a1

ID
ZDB-GENE-040426-1179
Name
aldehyde dehydrogenase 4 family, member A1
Symbol
aldh4a1 Nomenclature History
Previous Names
  • zgc:63592
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in oxidation-reduction process and proline catabolic process to glutamate. Predicted to localize to mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; optic tectum; optic vesicle; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aldh4a1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyperprolinemia type 2 Alliance Hyperprolinemia, type II 239510
Associated With aldh4a1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016160 Aldehyde dehydrogenase, cysteine active site
Conserved_site IPR029510 Aldehyde dehydrogenase, glutamic acid active site
Domain IPR015590 Aldehyde dehydrogenase domain
Family IPR005931 Delta-1-pyrroline-5-carboxylate dehydrogenase
Homologous_superfamily IPR016161 Aldehyde/histidinol dehydrogenase
Homologous_superfamily IPR016162 Aldehyde dehydrogenase, N-terminal
Homologous_superfamily IPR016163 Aldehyde dehydrogenase, C-terminal
Domain Details Per Protein
Protein Length Aldehyde dehydrogenase, C-terminal Aldehyde dehydrogenase, cysteine active site Aldehyde dehydrogenase domain Aldehyde dehydrogenase, glutamic acid active site Aldehyde dehydrogenase, N-terminal Aldehyde/histidinol dehydrogenase Delta-1-pyrroline-5-carboxylate dehydrogenase
UniProtKB:A0A140LG76 556
UniProtKB:Q7SY23 556
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations