ZFIN ID: ZDB-GENE-040426-1168
Gene Name: mitochondrial inner membrane protein MPV17
Gene Symbol: mpv17    Nomenclature History

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Previous Names: roy, tra, transparent, zgc:63573

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Involved in iridophore differentiation. Predicted to localize to cytoplasm. Is expressed in axis; eye; neural crest; notochord; and optic tectum. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2EE and mitochondrial DNA depletion syndrome 6. Orthologous to human MPV17 (mitochondrial inner membrane protein MPV17).
Genome Resources: Alliance (1),  Gene:394140 (1),  Ensembl(GRCz11):ENSDARG00000032431 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [MGC:63573]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a9 Small Deletion Intron 2 Splicing Variant, Frameshift, Premature Stop SPONTANEOUS
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b18 Small Deletion Unknown Frameshift, Premature Stop SPONTANEOUS
    sa39299 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zh706 Indel Exon 2 Unknown CRISPR
    zh707 Small Deletion Exon 3 Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mpv17
    1
    CRISPR2-mpv17 1
    CRISPR3-mpv17 1
    CRISPR4-mpv17
    1
    CRISPR5-mpv17
    1
    CRISPR6-mpv17
    1
    CRISPR7-mpv17
    1
    CRISPR8-mpv17
    1
    CRISPR9-mpv17
    1
    MO1-mpv17 N/A 1
    DISEASE ASSOCIATED WITH mpv17 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 2EE Alliance Charcot-Marie-Tooth disease, axonal, type 2EE 618400
    mitochondrial DNA depletion syndrome 6 Alliance Mitochondrial DNA depletion syndrome 6 (hepatocerebral type) 256810
    DISEASE ASSOCIATED WITH mpv17 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process iridophore differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mpv17-201 (1)    Ensembl 875
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mpv17 No data available
    MARKER RELATIONSHIPS
    mpv17 Contained in: [BAC] CH211-243J20 (1), CH211-245H14 (1)
    mpv17 Encodes: [cDNA] MGC:63573 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201165 (1) 1854 nt
    Genomic GenBank:BX569783 (1) 200617 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5TZ51 (1) 177 aa
    Sequence Information (all 14)
    ORTHOLOGY for mpv17 ( Chr: 20 )
    CITATIONS (399)