Gene
ptpn11b
- ID
- ZDB-GENE-040426-1158
- Name
- protein tyrosine phosphatase non-receptor type 11b
- Symbol
- ptpn11b Nomenclature History
- Previous Names
-
- SHP3 (1)
- zgc:63553
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables phosphatase activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be active in cytoplasm. Is expressed in head. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu5920 | Allele with one point mutation | Exon 3 | Premature Stop | ENU | |
| la028516Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7505 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa11037 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11510 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37695 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45799 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| juvenile myelomonocytic leukemia | Alliance | Leukemia, juvenile myelomonocytic, somatic | 607785 |
| metachondromatosis | Alliance | Metachondromatosis | 156250 |
| Noonan syndrome 1 | Alliance | Noonan syndrome 1 | 163950 |
| Noonan syndrome with multiple lentigines 1 | Alliance | LEOPARD syndrome 1 | 151100 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-6, -11 | SH2 domain | SH2 domain superfamily | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AYC9 | InterPro | 422 | ||||||||
| UniProtKB:Q7SY37 | InterPro | 592 | ||||||||
| UniProtKB:S6CMQ2 | InterPro | 590 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn11b-201
(1)
|
Ensembl | 3,241 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-203J19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-196B15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63553 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200454 (1) | 3246 nt | ||
| Genomic | GenBank:BX323989 (1) | 198365 nt | ||
| Polypeptide | UniProtKB:Q7SY37 (1) | 592 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | PTPN11 | 12 | Amino acid sequence comparison (2) |
- Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967
- Solman, M., Blokzijl-Franke, S., Piques, F., Yan, C., Yang, Q., Strullu, M., Kamel, S.M., Ak, P., Bakkers, J., Langenau, D.M., Cave, H., den Hertog, J. (2022) Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects. eLIFE. 11:
- Hale, A.J., den Hertog, J. (2017) Shp2-MAPK signalling drives proliferation during zebrafish embryo caudal fin-fold regeneration. Molecular and cellular biology. 38(4):e00515-17
- Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460
- Bonetti, M., Rodriguez-Martinez, V., Paardekooper Overman, J., Overvoorde, J., van Eekelen, M., Jopling, C., Hertog, J.d. (2014) Distinct and Overlapping Functions of ptpn11 Genes in Zebrafish Development. PLoS One. 9:e94884
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- Cannon, J.E., Place, E.S., Eve, A.M., Bradshaw, C.R., Sesay, A., Morrell, N.W., and Smith, J.C. (2013) Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mechanisms of Development. 130(2-3):122-131
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Liongue, C., O'Sullivan. L.A., Trengove, M.C., and Ward, A.C. (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One. 7(3):e32777
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
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