Gene

pde10a

ID
ZDB-GENE-040426-1115
Name
phosphodiesterase 10A
Symbol
pde10a Nomenclature History
Previous Names
  • zgc:56689
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in negative regulation of cGMP-mediated signaling and signal transduction. Is expressed in chordo neural hinge; epidermis; nervous system; and notochord. Orthologous to human PDE10A (phosphodiesterase 10A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Lambert et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pde10a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dyskinesia, limb and orofacial, infantile-onset 616921
Striatal degeneration, autosomal dominant 616922
Associated With pde10a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain IPR003018 GAF domain
Domain IPR003607 HD/PDEase domain
Family IPR023088 3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily IPR029016 GAF-like domain superfamily
Homologous_superfamily IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Domain Details Per Protein
Protein Length 3'5'-cyclic nucleotide phosphodiesterase 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily 3'5'-cyclic nucleotide phosphodiesterase, conserved site GAF domain GAF-like domain superfamily HD/PDEase domain
UniProtKB:A0A8M6Z293 852
UniProtKB:A0A0R4IJT4 794
UniProtKB:A0A8M6Z3S4 851
UniProtKB:A0A8M6Z9J5 851
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA pde10a-201 (1) Ensembl 2976 nt
mRNA pde10a-202 (1) Havana 2576 nt
mRNA pde10a-203 (1) Ensembl 2979 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations