ZFIN is now using GRCz12tu for Genomic Data
Gene
pde10a
- ID
- ZDB-GENE-040426-1115
- Name
- phosphodiesterase 10A
- Symbol
- pde10a Nomenclature History
- Previous Names
-
- zgc:56689
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP/PKA signal transduction and negative regulation of receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in cytosol. Is expressed in chordo neural hinge; epidermis; nervous system; and notochord. Human ortholog(s) of this gene implicated in striatal degeneration 2. Orthologous to human PDE10A (phosphodiesterase 10A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56689 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Lambert et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| striatal degeneration 2 | Alliance | Striatal degeneration, autosomal dominant | 616922 |
| Dyskinesia, limb and orofacial, infantile-onset | 616921 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003018 | GAF domain |
| Domain | IPR003607 | HD/PDEase domain |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
| Homologous_superfamily | IPR029016 | GAF-like domain superfamily |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | GAF domain | GAF-like domain superfamily | HD/PDEase domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z293 | InterPro | 852 | |||||||
| UniProtKB:A0A0R4IJT4 | InterPro | 794 | |||||||
| UniProtKB:A0A8M6Z3S4 | InterPro | 851 | |||||||
| UniProtKB:A0A8M6Z9J5 | InterPro | 851 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pde10a-201
(1)
|
Ensembl | 2,976 nt | ||
| mRNA |
pde10a-202
(1)
|
Ensembl | 2,576 nt | ||
| mRNA |
pde10a-203
(1)
|
Ensembl | 2,979 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers