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ZIRC
ZFIN ID: ZDB-GENE-040426-1090
Gene Name: ribonuclease H2, subunit B
Gene Symbol: rnaseh2b    Nomenclature History

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Previous Name: zgc:56602

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have RNA-DNA hybrid ribonuclease activity. Predicted to be involved in RNA catabolic process and ribonucleotide metabolic process. Predicted to localize to the nucleoplasm and ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Is expressed in several structures, including alar plate midbrain region; blood; immature eye; nervous system; and ventral mesenchyme. Orthologous to human RNASEH2B (ribonuclease H2 subunit B).
Genome Resources: Alliance (1),  Gene:393241 (1),  Ensembl(GRCz11):ENSDARG00000005128 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21501 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-rnaseh2b
    1
    CRISPR2-rnaseh2b
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rnaseh2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Aicardi-Goutieres syndrome Alliance Aicardi-Goutieres syndrome 2 610181
    DISEASE ASSOCIATED WITH rnaseh2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ribonucleotide metabolic process (more)
    Cellular Component ribonuclease H2 complex (more)
    Molecular Function RNA-DNA hybrid ribonuclease activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR019024 (1)
  • InterPro:IPR040456 (1)
  • InterPro:IPR041195 (1)
  • Pfam:PF09468 (1)
  • Pfam:PF17745 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript rnaseh2b-203 (1)    Ensembl 520
    mRNA rnaseh2b-201 (1)    Ensembl 1042
    ncRNA rnaseh2b-003 (1)    Ensembl 531
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rnaseh2b No data available
    MARKER RELATIONSHIPS
    rnaseh2b Contained in: [BAC] CH211-261I19 (1) (order this), DKEY-265J8 (1) (order this)
    rnaseh2b Encodes: [EST] eu349 (1)
    [cDNA] MGC:56602 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200271 (1) 1059 bp
    Genomic GenBank:CU855930 (1) 162434 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QE52 (1) 306 aa
    Sequence Clusters UniGene:78811 (1)
    Sequence Information (all 20)
    ORTHOLOGY for rnaseh2b ( Chr: 9 )
    CITATIONS (20)