Gene
piga
- ID
- ZDB-GENE-040426-1086
- Name
- phosphatidylinositol glycan anchor biosynthesis, class A
- Symbol
- piga Nomenclature History
- Previous Names
-
- im:6911675
- zgc:56589 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911675 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple congenital anomalies-hypotonia-seizures syndrome 2 | Alliance | Multiple congenital anomalies-hypotonia-seizures syndrome 2 | 300868 |
| paroxysmal nocturnal hemoglobinuria | Alliance | Paroxysmal nocturnal hemoglobinuria, somatic | 300818 |
| Neurodevelopmental disorder with epilepsy and hemochromatosis | 301072 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycosyl transferase, family 1 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-A/GPI3 | PIGA, GPI anchor biosynthesis |
|---|---|---|---|---|---|
| UniProtKB:B0S6Z8 | InterPro | 487 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available