ZFIN ID: ZDB-GENE-040426-1069
Gene Name: component of inhibitor of nuclear factor kappa B kinase complex
Gene Symbol: chuk    Nomenclature History

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Previous Names: ikk1 (1), IKKa (1), pky, zgc:56539

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to contribute to IkappaB kinase activity. Involved in several processes, including I-kappaB kinase/NF-kappaB signaling; epiboly involved in gastrulation with mouth forming second; and somite specification. Predicted to localize to the IkappaB kinase complex. Human ortholog(s) of this gene implicated in cocoon syndrome and prostate cancer. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).
Genome Resources: Alliance (1),  Gene:393287 (1),  Ensembl(GRCz11):ENSDARG00000011662 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56539]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018485Tg Transgenic Insertion Unknown Unknown DNA
p20ad Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35487 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35488 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chuk N/A 1
    DISEASE ASSOCIATED WITH chuk HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cocoon syndrome Alliance Cocoon syndrome 613630
    DISEASE ASSOCIATED WITH chuk VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process I-kappaB kinase/NF-kappaB signaling (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR022007 I-kappa-kinase-beta NEMO binding domain
    Domain IPR041185 IKBKB, scaffold dimerization domain
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chuk-201 (1)    Ensembl 3603
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM chuk No data available
    MARKER RELATIONSHIPS
    chuk Contained in: [BAC] DKEY-51A16 (1) (order this), DKEY-252G6 (1) (order this)
    chuk Encodes: [cDNA] MGC:56539 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200317 (1) 3321 nt
    Genomic GenBank:BX530079 (1) 166397 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QI37 (1) 801 aa
    Sequence Information (all 15)
    ORTHOLOGY for chuk ( Chr: 13 )
    CITATIONS (45)