Gene
clstn1
- ID
- ZDB-GENE-040426-1064
- Name
- calsyntenin 1
- Symbol
- clstn1 Nomenclature History
- Previous Names
-
- fm67g03
- wu:fk52g02
- wu:fm67g03
- zgc:153744
- zgc:56528 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including axon arborization; establishment or maintenance of microtubule cytoskeleton polarity; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and synapse. Predicted to be active in cell surface and postsynaptic membrane. Is expressed in several structures, including axis; musculature system; nervous system; neural tube; and tail bud. Orthologous to human CLSTN1 (calsyntenin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56528 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014397Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028538Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14307 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16000 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uw7 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| uw8 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| uw9 | Allele with one delins | Unknown | Frameshift | TALEN |
1 - 7 of 7
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-clstn1 | N/A | Ponomareva et al., 2014 |
| MO2-clstn1 | N/A | (2) |
| TALEN1-clstn1 | (4) |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin-like | Cadherin-like superfamily | Calsyntenin, C-terminal | Concanavalin A-like lectin/glucanase domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A9F2UUN9 | InterPro | 971 | ||||
| UniProtKB:A0A9F2Y9R0 | InterPro | 964 | ||||
| UniProtKB:A0A8M2B948 | InterPro | 981 | ||||
| UniProtKB:F1R520 | InterPro | 954 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
clstn1-201
(1)
|
Ensembl | 2,895 nt | ||
| mRNA |
clstn1-202
(1)
|
Ensembl | 3,658 nt | ||
| mRNA |
clstn1-203
(1)
|
Ensembl | 6,281 nt | ||
| mRNA |
clstn1-204
(1)
|
Ensembl | 1,065 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-259L18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-279E7 | ZFIN Curated Data | |
| Encodes | EST | fk52g02 | ||
| Encodes | EST | fm67g03 | ||
| Encodes | cDNA | MGC:56528 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153744 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:165444 | ZFIN Curated Data |
1 - 7 of 7
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077784 (1) | 3637 nt | ||
| Genomic | GenBank:BX571850 (1) | 236136 nt | ||
| Polypeptide | UniProtKB:A0A8M2B948 (1) | 981 aa |
- Sharma, D., Sehgal, P., Mathew, S., Vellarikkal, S.K., Singh, A.R., Kapoor, S., Jayarajan, R., Scaria, V., Sivasubbu, S. (2019) A genome-wide map of circular RNAs in adult zebrafish. Scientific Reports. 9:3432
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lee, T.J., Lee, J.W., Haynes, E.M., Eliceiri, K.W., Halloran, M.C. (2017) The Kinesin Adaptor Calsyntenin-1 Organizes Microtubule Polarity and Regulates Dynamics during Sensory Axon Arbor Development. Frontiers in Cellular Neuroscience. 11:107
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ortiz-Medina, H., Emond, M.R., Jontes, J.D. (2015) Zebrafish Calsyntenins mediate homophilic adhesion through their amino-terminal cadherin repeats. Neuroscience. 286:87-96
- Ponomareva, O.Y., Holmen, I.C., Sperry, A.J., Eliceiri, K.W., Halloran, M.C. (2014) Calsyntenin-1 Regulates Axon Branching and Endosomal Trafficking during Sensory Neuron Development In Vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:9235-48
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Crespo, B., Lan-Chow-Wing, O., Rocha, A., Zanuy, S., Gómez, A. (2013) foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. General and comparative endocrinology. 194:81-93
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gallagher, T.L., Arribere, J.A., Geurts, P.A., Exner, C.R., McDonald, K.L., Dill, K.K., Marr, H.L., Adkar, S.S., Garnett, A.T., Amacher, S.L., and Conboy, J.G. (2011) Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Developmental Biology. 359(2):251-61
1 - 10 of 13
Show