Gene
fancl
- ID
- ZDB-GENE-040426-1045
- Name
- FA complementation group L
- Symbol
- fancl Nomenclature History
- Previous Names
-
- zgc:66144
- zgc:76938
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within oocyte development. Predicted to be part of Fanconi anaemia nuclear complex. Predicted to be active in nucleus. Is expressed in central nervous system; eye; heart; intermediate cell mass of mesoderm; and reproductive system. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group L. Orthologous to human FANCL (FA complementation group L).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66144 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group L | Alliance | Fanconi anemia, complementation group L | 614083 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR019162 | Fanconi anemia complex, subunit FancL, WD-repeat containing domain |
| Domain | IPR026850 | FANCL C-terminal domain |
| Domain | IPR043898 | FANCL, UBC-like domain 2 |
| Domain | IPR044037 | FANCL, UBC-like domain 3 |
| Family | IPR026848 | E3 ubiquitin-protein ligase FANCL |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
| Homologous_superfamily | IPR043003 | FANCL, UBC-like domain 3 superfamily |
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase FANCL | FANCL C-terminal domain | FANCL, UBC-like domain 2 | FANCL, UBC-like domain 3 | FANCL, UBC-like domain 3 superfamily | Fanconi anemia complex, subunit FancL, WD-repeat containing domain | Ubiquitin-conjugating enzyme/RWD-like | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q9M3
|
316 | |||||||||
|
UniProtKB:Q6NY39
|
371 |
Interactions and Pathways
No data available
Plasmids
No data available