Gene

fancl

ID
ZDB-GENE-040426-1045
Name
FA complementation group L
Symbol
fancl Nomenclature History
Previous Names
  • zgc:66144
  • zgc:76938
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have ubiquitin-protein transferase activity. Involved in oocyte development. Predicted to localize to Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group L. Is expressed in central nervous system; eye; heart; intermediate cell mass of mesoderm; and reproductive system. Orthologous to human FANCL (FA complementation group L).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fancl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fanconi anemia complementation group L Alliance Fanconi anemia, complementation group L 614083
Associated With fancl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Domain IPR019162 Fanconi anemia complex, subunit FancL, WD-repeat containing domain
Domain IPR026850 FANCL C-terminal domain
Domain IPR043898 FANCL, UBC-like domain 2
Domain IPR044037 FANCL, UBC-like domain 3
Family IPR026848 E3 ubiquitin-protein ligase FANCL
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Homologous_superfamily IPR043003 FancL central domain, N-terminal
Domain Details Per Protein
Protein Length E3 ubiquitin-protein ligase FANCL FancL central domain, N-terminal FANCL C-terminal domain FANCL, UBC-like domain 2 FANCL, UBC-like domain 3 Fanconi anemia complex, subunit FancL, WD-repeat containing domain Ubiquitin-conjugating enzyme/RWD-like Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type
UniProtKB:Q6NY39 371
UniProtKB:Q1X868 371
UniProtKB:Q7SXP5 371
UniProtKB:B8JHS6 371
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations