Gene

idh3a

ID
ZDB-GENE-040426-1007
Name
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
Symbol
idh3a Nomenclature History
Previous Names
  • zgc:56380 (1)
  • zgc:85631
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; mesoderm; musculature system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la023252TgTransgenic insertionUnknownUnknownDNA
sa38087Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With idh3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 90 Alliance Retinitis pigmentosa 90 619007
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Associated With idh3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
Domain IPR024084 Isopropylmalate dehydrogenase-like domain
Family IPR004434 Isocitrate dehydrogenase NAD-dependent
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Domain Details Per Protein
Protein Additional Resources Length Isocitrate dehydrogenase NAD-dependent Isocitrate/isopropylmalate dehydrogenase, conserved site Isopropylmalate dehydrogenase-like domain
UniProtKB:A0A8M2BAG2 InterPro 204
UniProtKB:Q6NV33 InterPro 365
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA idh3a-201 (1) Ensembl 759 nt
mRNA idh3a-202 (1) Ensembl 1,438 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-200J6ZFIN Curated Data
EncodesESTfc54c04ZFIN Curated Data
EncodescDNAMGC:56380ZFIN Curated Data
EncodescDNAMGC:85631ZFIN Curated Data
EncodescDNAMGC:173889ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanIDH3A15
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseIdh3a9
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
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