Gene
sigmar1
- ID
- ZDB-GENE-040426-1006
- Name
- sigma non-opioid intracellular receptor 1
- Symbol
- sigmar1 Nomenclature History
- Previous Names
-
- oprs1
- zgc:56378 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including regulation of response to endoplasmic reticulum stress; retinal rod cell development; and swimming behavior. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in gut; head; muscle; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and autosomal recessive distal hereditary motor neuronopathy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56378 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sigmar1 | (2) | |
| MO1-sigmar1 | N/A | Moritz et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 16 | Alliance | ?Amyotrophic lateral sclerosis 16, juvenile | 614373 |
| autosomal recessive distal hereditary motor neuronopathy 2 | Alliance | ?Neuronopathy, distal hereditary motor, autosomal recessive 2 | 605726 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR006716 | ERG2/sigma1 receptor-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | ERG2/sigma1 receptor-like |
|---|---|---|---|
| UniProtKB:Q7ZWG9 | InterPro | 222 | |
| UniProtKB:A0A8M3B632 | InterPro | 124 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sigmar1-201
(1)
|
Ensembl | 1,154 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-262G12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56378 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200977 (1) | 1175 nt | ||
| Genomic | GenBank:BX927402 (2) | 155963 nt | ||
| Polypeptide | UniProtKB:Q7ZWG9 (1) | 222 aa |
- Crouzier, L., Danese, A., Yasui, Y., Richard, E.M., Liévens, J.C., Patergnani, S., Couly, S., Diez, C., Denus, M., Cubedo, N., Rossel, M., Thiry, M., Su, T.P., Pinton, P., Maurice, T., Delprat, B. (2022) Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models. Science Translational Medicine. 14:eabh3763
- Crouzier, L., Richard, E.M., Diez, C., Alzaeem, H., Denus, M., Cubedo, N., Delaunay, T., Glendenning, E., Baxendale, S., Liévens, J.C., Whitfield, T.T., Maurice, T., Delprat, B. (2022) Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human molecular genetics. 31(16):2711-2727
- Crouzier, L., Richard, E.M., Diez, C., Denus, M., Peyrel, A., Alzaeem, H., Cubedo, N., Delaunay, T., Maurice, T., Delprat, B. (2022) NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome. Molecular therapy. Methods & clinical development. 27:295-308
- Crouzier, L., Denus, M., Richard, E.M., Tavernier, A., Diez, C., Cubedo, N., Maurice, T., Delprat, B. (2021) Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish. International Journal of Molecular Sciences. 22(20):
- Yurtsever, İ., Üstündağ, Ü.V., Ünal, İ., Ateş, P.S., Emekli-Alturfan, E. (2020) Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish. Drug and chemical toxicology. 45(4):1544-1551
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Rennekamp, A.J., Huang, X.P., Wang, Y., Patel, S., Lorello, P.J., Cade, L., Gonzales, A.P., Yeh, J.J., Caldarone, B.J., Roth, B.L., Kokel, D., Peterson, R.T. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nature Chemical Biology. 12(7):552-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moritz, C., Berardi, F., Abate, C., Peri, F. (2015) Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries. Neuroscience letters. 591:13-8
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