Gene
sigmar1
- ID
- ZDB-GENE-040426-1006
- Name
- sigma non-opioid intracellular receptor 1
- Symbol
- sigmar1 Nomenclature History
- Previous Names
-
- oprs1
- zgc:56378 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including regulation of response to endoplasmic reticulum stress; retinal rod cell development; and swimming behavior. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in gut; head; muscle; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and autosomal recessive distal hereditary motor neuronopathy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56378 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 16 | Alliance | ?Amyotrophic lateral sclerosis 16, juvenile | 614373 |
| autosomal recessive distal hereditary motor neuronopathy 2 | Alliance | ?Neuronopathy, distal hereditary motor, autosomal recessive 2 | 605726 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR006716 | ERG2/sigma1 receptor-like |
Domain Details Per Protein
| Protein | Length | ERG2/sigma1 receptor-like |
|---|---|---|
|
UniProtKB:Q7ZWG9
|
222 | |
|
UniProtKB:A0A8M3B632
|
124 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sigmar1-201
(1)
|
Ensembl | 1,154 nt |
Interactions and Pathways
No data available
Plasmids
No data available