ZFIN is now using GRCz12tu for Genomic Data

Gene

rapgef1b

ID

ZDB-GENE-040426-1001

Name

Rap guanine nucleotide exchange factor (GEF) 1b

Symbol

rapgef1b Nomenclature History

Previous Names

rapgef1
zgc:56372 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Rap protein signal transduction; Ras protein signal transduction; and positive regulation of neuron projection development. Predicted to be active in plasma membrane. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56372 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rapgef1b Human Ortholog

No data available

Associated With rapgef1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019804	Ras guanine-nucleotide exchange factor, conserved site
Domain	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Family	IPR008937	Ras-like guanine nucleotide exchange factor
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:E7F4B2	InterPro	1188
UniProtKB:A0A8M9PQB1	InterPro	1203
UniProtKB:A0A8M9PI61	InterPro	1101
UniProtKB:A0A8M9P382	InterPro	1183
UniProtKB:A0A8M9PTQ9	InterPro	1204
UniProtKB:A0A8M9PCJ2	InterPro	1155
UniProtKB:A0AB32TBA4	InterPro	1167
UniProtKB:A0AB32TBK1	InterPro	1166
UniProtKB:A0AB32TD42	InterPro	1080
UniProtKB:A0AB32TEK4	InterPro	1063
UniProtKB:A0AB32TEU1	InterPro	1079
UniProtKB:A0AB32TF35	InterPro	1182
UniProtKB:A0AB32TGB9	InterPro	1064
UniProtKB:A0AC58I873	InterPro	1134
UniProtKB:A0AC58I880	InterPro	1084
UniProtKB:A0AC58I882	InterPro	1113
UniProtKB:A0AC58I885	InterPro	1138
UniProtKB:A0AC58I889	InterPro	1085
UniProtKB:A0AC58I892	InterPro	1139
UniProtKB:A0AC58I894	InterPro	1187
UniProtKB:A0AC58I898	InterPro	1100
UniProtKB:A0AC58I8A1	InterPro	1179
UniProtKB:A0AC58I8A4	InterPro	1118
UniProtKB:A0AC58I8A8	InterPro	1180
UniProtKB:A0AC58I8B0	InterPro	1134
UniProtKB:A0AC58I8B6	InterPro	1112
UniProtKB:A0AC58I8C4	InterPro	1056
UniProtKB:A0AC58I8C8	InterPro	1055

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rapgef1b-201 (1) Ensembl	Ensembl	4,332 nt	Select Tool ZFIN BLAST
mRNA	rapgef1b-203 (1) Ensembl	Ensembl	1,710 nt	Select Tool ZFIN BLAST
mRNA	rapgef1b-204 (1) Ensembl	Ensembl	2,119 nt	Select Tool ZFIN BLAST
ncRNA	rapgef1b-003 (1) Ensembl	Ensembl	944 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations