Gene

igfbp3

ID
ZDB-GENE-040412-1
Name
insulin-like growth factor binding protein 3
Symbol
igfbp3 Nomenclature History
Previous Names
  • IGFBP-3 (1)
  • zgc:91788
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Acts upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; otic vesicle formation; and pharyngeal system development. Located in nucleus. Is expressed in nervous system; neural crest telencephalon; otic vesicle; pectoral fin; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Zhong et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With igfbp3 Human Ortholog
No data available
Associated With igfbp3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
Domain IPR000716 Thyroglobulin type-1
Domain IPR000867 Insulin-like growth factor-binding protein, IGFBP
Family IPR012211 Insulin-like growth factor binding protein 3
Family IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
Domain Details Per Protein
Protein Length Growth factor receptor cysteine-rich domain superfamily Insulin-like growth factor binding protein 3 Insulin-like growth factor-binding protein family 1-6, chordata Insulin-like growth factor-binding protein, IGFBP Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site Thyroglobulin type-1 Thyroglobulin type-1 superfamily
UniProtKB:Q66I28 292
UniProtKB:A0A0R4IPP4 191
UniProtKB:Q90YJ6 292
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations