Gene
igfbp3
- ID
- ZDB-GENE-040412-1
- Name
- insulin-like growth factor binding protein 3
- Symbol
- igfbp3 Nomenclature History
- Previous Names
-
- IGFBP-3 (1)
- zgc:91788
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Acts upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; negative regulation of BMP signaling pathway; and otic vesicle formation. Located in nucleus. Is expressed in several structures, including female organism; nervous system; neural crest telencephalon; otic vesicle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91788 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhong et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23636 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017891 | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site |
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Family | IPR012211 | Insulin-like growth factor binding protein 3 |
| Family | IPR022321 | Insulin-like growth factor-binding protein family 1-6, chordata |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor binding protein 3 | Insulin-like growth factor-binding protein family 1-6, chordata | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66I28 | InterPro | 292 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfbp3-201
(1)
|
Ensembl | 806 nt | ||
| mRNA |
igfbp3-202
(1)
|
Ensembl | 3,093 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-140N19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-162M2 | ZFIN Curated Data | |
| Encodes | EST | fq35a06 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:91788 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205751 (1) | 3147 nt | ||
| Genomic | GenBank:CR926131 (1) | 125111 nt | ||
| Polypeptide | UniProtKB:Q66I28 (1) | 292 aa |
- Hui, J.C.M., Du, P., Webb, S.E., Liu, J.Y.H., Ngan, M.P., Lu, Z., Ng, H.S.H., Yang, L., Khalid, A., Liu, L., Li, Z., Deng, Y., Cui, D., Rudd, J.A. (2024) Imaging analytical technique to assess gastrointestinal motility in vivo using zebrafish larvae with diabetes mellitus-like traits. PLoS One. 19:e0314515e0314515
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Nys, N., Khatib, A.M., Siegfried, G. (2024) Apela promotes blood vessel regeneration and remodeling in zebrafish. Scientific Reports. 14:37183718
- Jamieson-Lucy, A.H., Kobayashi, M., James Aykit, Y., Elkouby, Y., Escobar-Aguirre, M., Vejnar, C., Giraldez, A., Mullins, M.C. (2022) A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb. Developmental Biology. 484:1-11
- Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., Li, H. (2022) Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences. 23(14):
- Zeng, N., Bao, J., Shu, T., Shi, C., Zhai, G., Jin, X., He, J., Lou, Q., Yin, Z. (2022) Sexual dimorphic effects of igf1 deficiency on metabolism in zebrafish. Frontiers in endocrinology. 13:879962
- Molagoda, I.M.N., Jayasingha, J.A.C.C., Choi, Y.H., Park, E.K., Jeon, Y.J., Lee, B.J., Kim, G.Y. (2020) Fermented Oyster Extract Promotes Insulin-Like Growth Factor-1-Mediated Osteogenesis and Growth Rate. Marine drugs. 18(9):
- Newman, M., Nik, H.M., Sutherland, G.T., Hin, N., Kim, W.S., Halliday, G.M., Jayadev, S., Smith, C., Laird, A., Lucas, C., Kittipassorn, T., Peet, D.J., Lardelli, M. (2020) Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1. Human molecular genetics. 29(14):2379-2394
- Wang, L., Yan, R., Yang, Q., Li, H., Zhang, J., Shimoda, Y., Kato, K., Yamanaka, K., An, Y. (2020) Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos. Ecotoxicology and environmental safety. 201:110820
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