Gene
aanat1
- ID
- ZDB-GENE-040329-1
- Name
- arylalkylamine N-acetyltransferase 1
- Symbol
- aanat1 Nomenclature History
- Previous Names
-
- aanat1a (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables acetyltransferase activity. Predicted to be involved in circadian rhythm and response to light stimulus. Predicted to act upstream of or within melatonin biosynthetic process and rhythmic process. Predicted to be active in cytoplasm. Is expressed in brain; epiphysis; ovary; and retina. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73074 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl-CoA N-acyltransferase | GNAT domain | Serotonin N-acetyltransferase-like |
|---|---|---|---|---|---|
| UniProtKB:Q6V7J8 | InterPro | 204 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aanat1-201
(1)
|
Ensembl | 1,621 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-274C18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73074 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200704 (1) | 1613 nt | ||
| Genomic | GenBank:CU062632 (1) | 88714 nt | ||
| Polypeptide | UniProtKB:Q6V7J8 (1) | 204 aa |
- Lee, J.H., Hwang, S.J., Ham, S.L., Kim, J., Bang, H.J., Park, J.S., Jang, H.H., Kim, T.Y., Park, J.W., Seo, Y.R., Kim, B.S., Kim, G.S., Lee, H.J., Kim, C.S. (2024) Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice. ACS omega. 9:438754388343875-43883
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Kumari, Y., Choo, B.K.M., Shaikh, M.F., Othman, I. (2019) Melatonin receptor agonist Piper betle L. ameliorates dexamethasone-induced early life stress in adult zebrafish. Experimental and Therapeutic Medicine. 18:1407-1416
- Li, M., Zhang, T., Jia, Y., Sun, Y., Zhang, S., Mi, P., Feng, Z., Zhao, X., Chen, D., Feng, X. (2019) Combined treatment of melatonin and sodium tanshinone IIA sulfonate reduced the neurological and cardiovascular toxicity induced by deltamethrin in zebrafish. Chemosphere. 243:125373
- Ping, M., Qiu-Ping, Z., Shi-Bao, L., Xing-Yu, L., Shu-Hui, Z., Meng, L., Dong-Yan, C., Xin, Z., Dao-Fu, F., Feng, X.Z. (2018) Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene-9-bisphenol in zebrafish (Danio rerio). Journal of pineal research. 66(1):e12530
- Ramasamy, S., Sharma, S., Iyengar, B.R., Vellarikkal, S.K., Sivasubbu, S., Maiti, S., Pillai, B. (2018) Identification of novel circadian transcripts in the zebrafish retina. The Journal of experimental biology. 222(Pt 1):
- Ratanayotha, A., Kawai, T., Higashijima, S.I., Okamura, Y. (2017) Molecular and functional characterization of the voltage-gated proton channel in zebrafish neutrophils. Physiological Reports. 5(15)
- Khan, Z.A., Yumnamcha, T., Rajiv, C., Devi, H.S., Mondal, G., Dharmajyoti Devi, S., Bharali, R., Chattoraj, A. (2016) Melatonin Biosynthesizing Enzyme Genes and Clock Genes in Ovary and Whole Brain of Zebrafish (Danio rerio): Differential Expression and a Possible Interplay. General and comparative endocrinology. 233:16-31
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gandhi, A.V., Mosser, E.A., Oikonomou, G., Prober, D.A. (2015) Melatonin Is Required for the Circadian Regulation of Sleep. Neuron. 85(6):1193-9
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