Gene
rhoab
- ID
- ZDB-GENE-040322-2
- Name
- ras homolog gene family, member Ab
- Symbol
- rhoab Nomenclature History
- Previous Names
-
- arha
- rhoa
- wu:fj42e08 (1)
- zgc:92206
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within several processes, including Rho protein signal transduction; establishment of mitotic spindle localization; and post-anal tail morphogenesis. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including germ ring; nervous system; notochord; pleuroperitoneal region; and tail bud. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies, somatic mosaic | 618727 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QIE1 | InterPro | 193 | ||||
| UniProtKB:Q6DHM9 | InterPro | 193 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids