Gene

rhoab

ID
ZDB-GENE-040322-2
Name
ras homolog gene family, member Ab
Symbol
rhoab Nomenclature History
Previous Names
  • arha
  • rhoa
  • wu:fj42e08 (1)
  • zgc:92206
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within several processes, including Rho protein signal transduction; establishment of mitotic spindle localization; and post-anal tail morphogenesis. Predicted to be located in membrane. Predicted to be active in several cellular components, including cell cortex; cleavage furrow; and dendritic spine. Is expressed in several structures, including germ ring; nervous system; notochord; pleuroperitoneal region; and tail bud. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rhoab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies, somatic mosaic 618727
Associated With rhoab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR003578 Small GTPase Rho
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase Rho Small GTP-binding protein domain
UniProtKB:A0A2R8QBD2 136
UniProtKB:Q6DHM9 193
UniProtKB:Q800Q4 193
UniProtKB:A7MCP4 193
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations