Gene
rhoab
- ID
- ZDB-GENE-040322-2
- Name
- ras homolog gene family, member Ab
- Symbol
- rhoab Nomenclature History
- Previous Names
-
- arha
- rhoa
- wu:fj42e08 (1)
- zgc:92206
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within several processes, including Rho protein signal transduction; establishment of mitotic spindle localization; and post-anal tail morphogenesis. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including germ ring; nervous system; notochord; pleuroperitoneal region; and tail bud. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies, somatic mosaic | 618727 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QIE1 | InterPro | 193 | ||||
| UniProtKB:Q6DHM9 | InterPro | 193 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Li, Z., Li, B., Wang, J., Lu, Y., Chen, A.F.Y., Sun, K., Yu, Y., Chen, S. (2021) GAA deficiency promotes angiogenesis through upregulation of Rac1 induced by autophagy disorder. Biochimica et biophysica acta. Molecular cell research. 1868(5):118969
- Kuroda, J., Itabashi, T., Iwane, A.H., Aramaki, T., Kondo, S. (2020) The Physical Role of Mesenchymal Cells Driven by the Actin Cytoskeleton Is Essential for the Orientation of Collagen Fibrils in Zebrafish Fins. Frontiers in cell and developmental biology. 8:580520
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Ivanova, A.S., Korotkova, D.D., Ermakova, G.V., Martynova, N.Y., Zaraisky, A.G., Tereshina, M.B. (2018) Ras-dva small GTPases lost during evolution of amniotes regulate regeneration in anamniotes. Scientific Reports. 8:13035
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Goodman, L., Zallocchi, M. (2017) Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells. Journal of Cell Science. 130:3698-3712
- Blokhuis, A.M., Koppers, M., Groen, E.J., van den Heuvel, D.M., Dini Modigliani, S., Anink, J.J., Fumoto, K., van Diggelen, F., Snelting, A., Sodaar, P., Verheijen, B.M., Demmers, J.A., Veldink, J.H., Aronica, E., Bozzoni, I., den Hertog, J., van den Berg, L.H., Pasterkamp, R.J. (2016) Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways. Acta Neuropathologica. 132(2):175-96
- Dai, Y., Prithiviraj, N., Gan, J., Zhang, X.A., Yan, J. (2016) Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Scientific Reports. 6:38693
- Rosowski, E.E., Deng, Q., Keller, N.P., Huttenlocher, A. (2016) Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 197(12):4780-4790
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