Gene
nos2a
- ID
- ZDB-GENE-040305-1
- Name
- nitric oxide synthase 2a, inducible
- Symbol
- nos2a Nomenclature History
- Previous Names
-
- inosa
- nos2 (1)
- inducible nitric oxide synthase a
- si:dkey-57m14.4
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable FMN binding activity; flavin adenine dinucleotide binding activity; and nitric-oxide synthase activity. Acts upstream of or within response to glucose; response to lipopolysaccharide; and response to wounding. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in several structures, including brain; digestive system; head; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu740 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025102Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14328 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14427 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38498 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sou16 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nos2a | (2) | |
| CRISPR2-nos2a | Yu et al., 2024 | |
| MO1-nos2a | N/A | (2) |
| MO2-nos2a | N/A | North et al., 2009 |
| MO3-nos2a | N/A | (6) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Malaria, resistance to} | 611162 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001094 | Flavodoxin-like |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR001709 | Flavoprotein pyridine nucleotide cytochrome reductase |
| Domain | IPR003097 | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
| Domain | IPR004030 | Nitric oxide synthase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavodoxin-like | Flavodoxin/nitric oxide synthase | Flavoprotein-like superfamily | Flavoprotein pyridine nucleotide cytochrome reductase | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Nitric oxide synthase, domain 1 superfamily | Nitric oxide synthase, domain 2 superfamily | Nitric oxide synthase, domain 3 superfamily | Nitric-oxide synthase, eukaryote | Nitric Oxide Synthase (NOS) | Nitric oxide synthase, N-terminal | Nitric oxide synthase, N-terminal domain superfamily | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A2BIN8 | InterPro | 1079 | |||||||||||||||||
| UniProtKB:A7WK81 | InterPro | 1079 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-nos2 | monoclonal | IgG2a | Mouse |
|
BD Biosciences
|
5 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-57M14 | ||
| Encodes | EST | eu740 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001104937 (1) | 3382 nt | ||
| Genomic | GenBank:BX950211 (2) | 134143 nt | ||
| Polypeptide | UniProtKB:A2BIN8 (1) | 1079 aa |
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- Hasan, M., Zedan, H.T., Al-Fakhroo, D., Elsayed Ibrahim, H., Abiib, S.I., El-Sherbiny, I.M., Yalcin, H.C. (2024) In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model. Nitric oxide : biology and chemistry. 144:47-57
- Huang, Y., Chen, Y., Xie, H., Feng, Y., Chen, S., Bao, B. (2024) Effects of Inducible Nitric Oxide Synthase (iNOS) Gene Knockout on the Diversity, Composition, and Function of Gut Microbiota in Adult Zebrafish. Biology. 13(6):
- Hui, J.C.M., Du, P., Webb, S.E., Liu, J.Y.H., Ngan, M.P., Lu, Z., Ng, H.S.H., Yang, L., Khalid, A., Liu, L., Li, Z., Deng, Y., Cui, D., Rudd, J.A. (2024) Imaging analytical technique to assess gastrointestinal motility in vivo using zebrafish larvae with diabetes mellitus-like traits. PLoS One. 19:e0314515e0314515
- Li, L., He, Y.L., Xu, N., Wang, X.F., Song, B., Tang, B.Q., Lee, S.M. (2024) A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Redox Biology. 70:103057103057
- Nayak, S.P.R.R., Basty, C., Boopathi, S., Dhivya, L.S., Alarjani, K.M., Gawwad, M.R.A., Hager, R., Kathiravan, M.K., Arockiaraj, J. (2024) Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection. Journal of microbiology (Seoul, Korea). 62(2):75-89
- Raas, Q., Wood, A., Stevenson, T.J., Swartwood, S., Liu, S., Kannan, R.M., Kannan, S., Bonkowsky, J.L. (2024) Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model. Frontiers in pediatrics. 12:13268861326886
- Ranjan, G., Sehgal, P., Scaria, V., Sivasubbu, S. (2024) SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. EMBO reports. 25(11):4950-4978
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Cao, P., Cheng, Y., Li, Z., Cheng, Y.J., Chu, X., Geng, C., Yin, X., Li, Y. (2023) Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration. Journal of nanobiotechnology. 21:4444
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