Gene

nos2a

ID
ZDB-GENE-040305-1
Name
nitric oxide synthase 2a, inducible
Symbol
nos2a Nomenclature History
Previous Names
  • inosa
  • nos2 (1)
  • inducible nitric oxide synthase a
  • si:dkey-57m14.4
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have NADPH-hemoprotein reductase activity; coenzyme binding activity; and nitric-oxide synthase activity. Involved in response to glucose; response to lipopolysaccharide; and response to wounding. Predicted to localize to several cellular components, including cytosol; nucleus; and vesicle membrane. Is expressed in several structures, including brain; digestive system; head; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nos2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Malaria, resistance to} 611162
Associated With nos2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001094 Flavodoxin-like
Domain IPR001433 Oxidoreductase FAD/NAD(P)-binding
Domain IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
Domain IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Domain IPR004030 Nitric oxide synthase, N-terminal
Domain IPR008254 Flavodoxin/nitric oxide synthase
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Family IPR012144 Nitric-oxide synthase, eukaryote
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Homologous_superfamily IPR029039 Flavoprotein-like superfamily
Homologous_superfamily IPR036119 Nitric oxide synthase, N-terminal domain superfamily
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Flavodoxin-like Flavodoxin/nitric oxide synthase Flavoprotein-like superfamily Flavoprotein pyridine nucleotide cytochrome reductase NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily Nitric-oxide synthase, eukaryote Nitric oxide synthase, N-terminal Nitric oxide synthase, N-terminal domain superfamily Oxidoreductase FAD/NAD(P)-binding Riboflavin synthase-like beta-barrel Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
UniProtKB:A2BIN8 1079
UniProtKB:Q7T1G1 164
UniProtKB:A7WK81 1079
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-nos2 monoclonal IgG2a Mouse
  • IHC
  • WB
BD Biosciences
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations