Gene
nos2a
- ID
- ZDB-GENE-040305-1
- Name
- nitric oxide synthase 2a, inducible
- Symbol
- nos2a Nomenclature History
- Previous Names
-
- inosa
- nos2 (1)
- inducible nitric oxide synthase a
- si:dkey-57m14.4
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable FMN binding activity; flavin adenine dinucleotide binding activity; and nitric-oxide synthase activity. Acts upstream of or within response to glucose; response to lipopolysaccharide; and response to wounding. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in several structures, including brain; digestive system; head; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu740 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Malaria, resistance to} | 611162 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001094 | Flavodoxin-like |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR001709 | Flavoprotein pyridine nucleotide cytochrome reductase |
| Domain | IPR003097 | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
| Domain | IPR004030 | Nitric oxide synthase, N-terminal |
| Domain | IPR008254 | Flavodoxin/nitric oxide synthase |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Family | IPR012144 | Nitric-oxide synthase, eukaryote |
| Family | IPR050607 | Nitric Oxide Synthase (NOS) |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR023173 | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily |
| Homologous_superfamily | IPR029039 | Flavoprotein-like superfamily |
| Homologous_superfamily | IPR036119 | Nitric oxide synthase, N-terminal domain superfamily |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
| Homologous_superfamily | IPR044940 | Nitric oxide synthase, domain 2 superfamily |
| Homologous_superfamily | IPR044943 | Nitric oxide synthase, domain 1 superfamily |
| Homologous_superfamily | IPR044944 | Nitric oxide synthase, domain 3 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavodoxin-like | Flavodoxin/nitric oxide synthase | Flavoprotein-like superfamily | Flavoprotein pyridine nucleotide cytochrome reductase | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Nitric oxide synthase, domain 1 superfamily | Nitric oxide synthase, domain 2 superfamily | Nitric oxide synthase, domain 3 superfamily | Nitric-oxide synthase, eukaryote | Nitric Oxide Synthase (NOS) | Nitric oxide synthase, N-terminal | Nitric oxide synthase, N-terminal domain superfamily | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A2BIN8 | InterPro | 1079 | |||||||||||||||||
| UniProtKB:A7WK81 | InterPro | 1079 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-nos2 | monoclonal | IgG2a | Mouse |
|
BD Biosciences
|
5 |
Plasmids
No data available