ZFIN is now using GRCz12tu for Genomic Data
Gene
ldb3a
- ID
- ZDB-GENE-040121-6
- Name
- LIM domain binding 3a
- Symbol
- ldb3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Acts upstream of or within several processes, including locomotory behavior; skeletal muscle tissue development; and somitogenesis. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Is expressed in several structures, including adaxial cell; intestine; musculature system; pericardial region; and sensory system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to human LDB3 (LIM domain binding 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56098 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1C | Alliance | Cardiomyopathy, dilated, 1C, with or without LVNC | 601493 |
| dilated cardiomyopathy 1C | Alliance | Cardiomyopathy, hypertrophic, 24 | 601493 |
| dilated cardiomyopathy 1C | Alliance | Left ventricular noncompaction 3 | 601493 |
| myofibrillar myopathy 4 | Alliance | Myopathy, myofibrillar, 4 | 609452 |
| Cardiomyopathy, dilated, 2L | 621237 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PDZ and LIM domain-containing | PDZ and LIM domain protein 1-4/Zasp-like, middle domain | PDZ domain | PDZ superfamily | Zasp-like motif | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVD3 | InterPro | 291 | ||||||
| UniProtKB:A0A8M9Q9Y7 | InterPro | 746 | ||||||
| UniProtKB:A0AB32SZI8 | InterPro | 649 | ||||||
| UniProtKB:A0AB32T1N2 | InterPro | 588 | ||||||
| UniProtKB:A0AB32T1X3 | InterPro | 580 | ||||||
| UniProtKB:A0AB32T2E1 | InterPro | 596 | ||||||
| UniProtKB:A0AB32T3E9 | InterPro | 291 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
ldb3a-211
(1)
|
Ensembl | 1,516 nt | ||
| mRNA |
ldb3a-201
(1)
|
Ensembl | 852 nt | ||
| mRNA |
ldb3a-202
(1)
|
Ensembl | 780 nt | ||
| mRNA |
ldb3a-203
(1)
|
Ensembl | 900 nt | ||
| mRNA |
ldb3a-204
(1)
|
Ensembl | 1,322 nt | ||
| mRNA |
ldb3a-205
(1)
|
Ensembl | 4,619 nt | ||
| mRNA |
ldb3a-206
(1)
|
Ensembl | 1,791 nt | ||
| mRNA |
ldb3a-207
(1)
|
Ensembl | 2,191 nt | ||
| mRNA |
ldb3a-208
(1)
|
Ensembl | 777 nt | ||
| mRNA |
ldb3a-209
(1)
|
Ensembl | 1,767 nt | ||
| mRNA |
ldb3a-210
(1)
|
Ensembl | 791 nt | ||
| mRNA |
ldb3a-212
(1)
|
Ensembl | 2,119 nt | ||
| mRNA |
ldb3a-213
(1)
|
Ensembl | 856 nt | ||
| mRNA |
ldb3a-214
(1)
|
Ensembl | 925 nt | ||
| mRNA |
ldb3a-215
(1)
|
Ensembl | 911 nt | ||
| mRNA |
ldb3a-216
(1)
|
Ensembl | 867 nt | ||
| mRNA |
ldb3a-217
(1)
|
Ensembl | 880 nt | ||
| mRNA |
ldb3a-218
(1)
|
Ensembl | 2,507 nt | ||
| mRNA |
ldb3a-219
(1)
|
Ensembl | 1,592 nt | ||
| mRNA |
ldb3a-220
(1)
|
Ensembl | 1,745 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers