Gene
sh3gl3b
- ID
- ZDB-GENE-040121-4
- Name
- SH3-domain GRB2-like 3b
- Symbol
- sh3gl3b Nomenclature History
- Previous Names
-
- sh3gl3
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Acts upstream of or within blood vessel lumenization. Predicted to be located in early endosome and membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in blood island; notochord; posterior lateral mesoderm; and vasculature. Orthologous to human SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55890 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-sh3gl3b | N/A | (2) |
| MO2-sh3gl3b | N/A | Zhao et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | BAR domain | Endophilin-A, SH3 domain | Endophilin/SH3RF | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TGT7 | InterPro | 386 | ||||||
| UniProtKB:A0A2R8QD99 | InterPro | 375 | ||||||
| UniProtKB:A0A8M3AWG7 | InterPro | 317 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sh3gl3b-201
(1)
|
Ensembl | 2,161 nt | ||
| mRNA |
sh3gl3b-202
(1)
|
Ensembl | 873 nt | ||
| mRNA |
sh3gl3b-203
(1)
|
Ensembl | 2,975 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-59O9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55890 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192915 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200181 (1) | 1808 nt | ||
| Genomic | GenBank:CR385081 (2) | 182806 nt | ||
| Polypeptide | UniProtKB:Q6TGT7 (1) | 386 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhao, Y., and Lin, S. (2013) Essential Role of Sh3gl3 for Vascular Lumen Maintenance in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1280-6
- Gomez, G.A., Veldman, M.B., Zhao, Y., Burgess, S., and Lin, S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS One. 4(3):e4994
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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