Gene
nop56
- ID
- ZDB-GENE-040109-1
- Name
- NOP56 ribonucleoprotein homolog
- Symbol
- nop56 Nomenclature History
- Previous Names
-
- nol5a
- NOP56 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable snoRNA binding activity. Acts upstream of or within several processes, including central nervous system development; swimming behavior; and thigmotaxis. Predicted to be located in nucleolus. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Is expressed in head and midbrain. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi3101Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la010165Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12582 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3984 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| zf3985 | Allele with one insertion | Exon 4 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 36 | Alliance | Spinocerebellar ataxia 36 | 614153 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nop, C-terminal domain | Nop domain | Nop domain superfamily | NOSIC | Nucleolar protein 58/56, N-terminal | Nucleolar protein Nop56/Nop58 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DRE5 | InterPro | 548 | ||||||
| UniProtKB:A0A8M1P758 | InterPro | 366 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
nop56-201
(1)
|
Ensembl | 836 nt | ||
| aberrant processed transcript |
nop56-202
(1)
|
Ensembl | 1,134 nt | ||
| mRNA |
nop56-203
(1)
|
Ensembl | 2,039 nt | ||
| ncRNA |
nop56-003
(1)
|
Ensembl | 826 nt | ||
| ncRNA |
nop56-004
(1)
|
Ensembl | 794 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260M19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201217 (1) | 2259 nt | ||
| Genomic | GenBank:CT027620 (1) | 162438 nt | ||
| Polypeptide | UniProtKB:Q6DRE5 (1) | 548 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | NOP56 | 20 | Amino acid sequence comparison (2) |