Gene

ahcy

ID
ZDB-GENE-031219-6
Name
adenosylhomocysteinase
Symbol
ahcy Nomenclature History
Previous Names
  • cb1079 (1)
  • dtp (1)
  • ducttrip (1)
  • hm:zeh1173 (1)
  • hm:zeh1364
  • wu:fj67b02
  • zeh1173
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have adenosylhomocysteinase activity. Involved in S-adenosylmethionine cycle. Predicted to localize to cytosol. Is expressed in several structures, including brain; digestive system; immature eye; musculature system; and neural tube. Used to study fatty liver disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ahcy Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase Alliance Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase 613752
Associated With ahcy Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site
Domain IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Family IPR000043 Adenosylhomocysteinase-like
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Homologous_superfamily IPR042172 Adenosylhomocysteinase-like superfamily
Domain Details Per Protein
Protein Length Adenosylhomocysteinase-like Adenosylhomocysteinase-like superfamily NAD(P)-binding domain superfamily S-adenosyl-L-homocysteine hydrolase, conserved site S-adenosyl-L-homocysteine hydrolase, NAD binding domain
UniProtKB:Q803T5 433
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations