Gene
cyp4t8
- ID
- ZDB-GENE-031219-3
- Name
- cytochrome P450, family 4, subfamily T, polypeptide 8
- Symbol
- cyp4t8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be located in membrane. Is expressed in myotome; nervous system; otic vesicle; pharyngeal arch 3-7 skeleton; and somite. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4B1 (cytochrome P450 family 4 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1041 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 Monooxygenases | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PH32 | InterPro | 458 | |||||
| UniProtKB:E7FB64 | InterPro | 509 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp4t8-201
(1)
|
Ensembl | 1,808 nt | ||
| mRNA |
cyp4t8-202
(1)
|
Ensembl | 1,811 nt | ||
| ncRNA |
cyp4t8-003
(1)
|
Ensembl | 653 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-256M12 | ZFIN Curated Data | |
| Encodes | EST | cb1041 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:66042 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199216 (1) | 1858 nt | ||
| Genomic | GenBank:CR388060 (1) | 213586 nt | ||
| Polypeptide | UniProtKB:E7FB64 (1) | 509 aa |
No data available
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
- Monroe, J.D., Fraher, D., Huang, X., Mellett, N.A., Meikle, P.J., Sinclair, A.J., Lirette, S.T., Maihle, N.J., Gong, Z., Gibert, Y. (2022) Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish. Cancer & metabolism. 10:7
- Tête, A., Gallais, I., Imran, M., Legoff, L., Martin-Chouly, C., Sparfel, L., Bescher, M., Sergent, O., Podechard, N., Lagadic-Gossmann, D. (2020) MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 146:111798
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572
- Ho, J.C., Hsiao, C.D., Kawakami, K., Tse, W.K. (2016) Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 173:29-35
- Lu, J.W., Yang, W.Y., Lin, Y.M., Jin, S.L., and Yuh, C.H. (2013) Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta histochemica. 115(7):728-39
- Lu, J.W., Yang, W.Y., Tsai, S.M., Lin, Y.M., Chang, P.H., Chen, J.R., Wang, H.D., Wu, J.L., Jin, S.L., and Yuh, C.H. (2013) Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish. PLoS One. 8(10):e76951
- Nussbaum, J.M., Liu, L.J., Hasan, S.A., Schaub, M., McClendon, A., Stainier, D.Y., and Sakaguchi, T.F. (2013) Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis. Hepatology (Baltimore, Md.). 58(4):1326-1338
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