Gene

pkma

ID
ZDB-GENE-031201-4
Name
pyruvate kinase M1/2a
Symbol
pkma Nomenclature History
Previous Names
  • pkm2
  • pkm2a
  • cb1029 (1)
  • fj33f03
  • wu:fj33f03 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable pyruvate kinase activity. Involved in sprouting angiogenesis. Predicted to be active in cytoplasm. Is expressed in several structures, including nervous system; neural tube; otic vesicle; pericardial region; and solid lens vesicle. Orthologous to human PKM (pyruvate kinase M1/2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Stone et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pkma Human Ortholog
No data available
Associated With pkma Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018209 Pyruvate kinase, active site
Domain IPR015793 Pyruvate kinase, barrel
Domain IPR015795 Pyruvate kinase, C-terminal
Family IPR001697 Pyruvate kinase
Homologous_superfamily IPR011037 Pyruvate kinase-like, insert domain superfamily
Homologous_superfamily IPR015806 Pyruvate kinase, insert domain superfamily
Homologous_superfamily IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Homologous_superfamily IPR036918 Pyruvate kinase, C-terminal domain superfamily
Homologous_superfamily IPR040442 Pyruvate kinase-like domain superfamily
Domain Details Per Protein
Protein Length Pyruvate kinase Pyruvate kinase, active site Pyruvate kinase, barrel Pyruvate kinase, C-terminal Pyruvate kinase, C-terminal domain superfamily Pyruvate kinase, insert domain superfamily Pyruvate kinase-like domain superfamily Pyruvate kinase-like, insert domain superfamily Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
UniProtKB:Q6NXD1 532
UniProtKB:A0A0R4IGP6 532
UniProtKB:A0A0R4IAV3 66
UniProtKB:A0A0R4IAN1 89
UniProtKB:Q7ZVT2 532
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations