Gene
supt16h
- ID
- ZDB-GENE-031118-96
- Name
- SPT16 homolog, facilitates chromatin remodeling subunit
- Symbol
- supt16h Nomenclature History
- Previous Names
-
- spt16 (1)
- fq44d08
- wu:fq44d08
- zgc:194708
- zgc:194732
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable nucleosome binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to act upstream of or within DNA damage response and DNA replication. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex. Is expressed in dorsal aorta; hematopoietic multipotent progenitor cell; neural tube; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Espanola et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Espanola et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with dysmorphic facies and thin corpus callosum | Alliance | Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum | 619480 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000994 | Peptidase M24 |
| Domain | IPR013719 | Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain |
| Domain | IPR033825 | FACT complex subunit Spt16, peptidase M24-like domain |
| Domain | IPR048969 | FACT complex subunit SPT16, C-terminal domain |
| Family | IPR040258 | FACT complex subunit Spt16 |
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Domain Details Per Protein
| Protein | Length | Creatinase/aminopeptidase-like | Creatinase/Aminopeptidase P/Spt16, N-terminal | FACT complex subunit Spt16 | FACT complex subunit SPT16, C-terminal domain | FACT complex subunit Spt16, peptidase M24-like domain | Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain | Peptidase M24 | PH-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A5A4L9
|
1033 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
supt16h-201
(1)
|
Ensembl | 8,455 nt | ||
| mRNA |
supt16h-202
(1)
|
Ensembl | 3,917 nt | ||
| mRNA |
supt16h-203
(1)
|
Ensembl | 8,455 nt | ||
| mRNA |
supt16h-204
(1)
|
Ensembl | 195 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225L7 | ZFIN Curated Data | |
| Encodes | EST | fq44d08 | ||
| Encodes | cDNA | MGC:194708 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194732 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001097584 (1) | 3917 nt | ||
| Genomic | GenBank:BX248243 (2) | 161572 nt | ||
| Polypeptide | UniProtKB:A5A4L9 (1) | 1033 aa |
- Qian, P., Kang, J., Liu, D., Xie, G. (2022) Single Cell Transcriptome Sequencing of Zebrafish Testis Revealed Novel Spermatogenesis Marker Genes and Stronger Leydig-Germ Cell Paracrine Interactions. Frontiers in genetics. 13:851719
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Espanola, S.G., Song, H., Ryu, E., Saxena, A., Kim, E.S., Manegold, J.E., Nasamran, C.A., Sahoo, D., Oh, C.K., Bickers, C., Shin, U., Grainger, S., Park, Y.H., Pandolfo, L., Kang, M.S., Kang, S., Myung, K., Cooper, K.L., Yelon, D., Traver, D., Lee, Y. (2020) Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Nature cell biology. 22(12):1411-1422
- Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Singh, S.K., Aravamudhan, S., Armant, O., Krüger, M., Grabher, C. (2014) Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Fish & shellfish immunology. 40(1):217-24
- Bai, X., Kim, J., Yang, Z., Jurynec, M.J., Akie, T.E., Lee, J., LeBlanc, J., Sessa, A., Jiang, H., DiBiase, A., Zhou, Y., Grunwald, D.J., Lin, S., Cantor, A.B., Orkin, S.H., and Zon, L.I. (2010) TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142(1):133-143
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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