Gene
idh2
- ID
- ZDB-GENE-031118-95
- Name
- isocitrate dehydrogenase (NADP(+)) 2
- Symbol
- idh2 Nomenclature History
- Previous Names
-
- wu:fb33c06
- wu:fk31e05
- wu:fq43b01
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have NAD binding activity; isocitrate dehydrogenase (NADP+) activity; and magnesium ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; and intrahepatic cholangiocarcinoma. Is expressed in several structures, including blastoderm; brain; digestive system; pectoral fin bud; and renal system. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55485 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| D-2-hydroxyglutaric aciduria 2 | Alliance | D-2-hydroxyglutaric aciduria 2 | 613657 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Isocitrate dehydrogenase NADP-dependent | Isocitrate/isopropylmalate dehydrogenase, conserved site | Isopropylmalate dehydrogenase-like domain |
|---|---|---|---|---|
|
UniProtKB:A0A0G2L6I6
|
||||
|
UniProtKB:E7F4R9
|
||||
|
UniProtKB:Q7ZUP6
|
449 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance