aco1

ID

ZDB-GENE-031118-76

Name

aconitase 1, soluble

Symbol

aco1 Nomenclature History

Previous Names

IRP1 (1)
wu:fo75b03

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable aconitate hydratase activity; iron-responsive element binding activity; and iron-sulfur cluster binding activity. Predicted to be involved in citrate metabolic process and intracellular iron ion homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in blood and presumptive blood. Orthologous to human ACO1 (aconitase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Haunhorst et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aco1 Human Ortholog

No data available

Associated With aco1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018136	Aconitase family, 4Fe-4S cluster binding site
Domain	IPR000573	Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
Domain	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
Domain	IPR044137	Aconitase A, swivel domain
Family	IPR006249	Aconitase/Iron-responsive element-binding protein 2
Homologous_superfamily	IPR015928	Aconitase/3-isopropylmalate dehydratase, swivel
Homologous_superfamily	IPR015931	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
Homologous_superfamily	IPR036008	Aconitase, iron-sulfur domain