Gene

ntf3

ID
ZDB-GENE-031118-66
Name
neurotrophin 3
Symbol
ntf3 Nomenclature History
Previous Names
  • NT-3 (1)
  • ntf3-pen
  • wu:fl98d04
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have growth factor activity and nerve growth factor receptor binding activity. Involved in negative regulation of programmed cell death and peripheral nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including brain; cardiovascular system; otic placode; pancreas primordium; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ntf3 Human Ortholog
No data available
Associated With ntf3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019846 Nerve growth factor conserved site
Domain IPR002072 Nerve growth factor-related
Family IPR015578 Neurotrophin-3
Family IPR020408 Nerve growth factor-like
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Nerve growth factor conserved site Nerve growth factor-like Nerve growth factor-related Neurotrophin-3
UniProtKB:Q568T2 294
UniProtKB:F1QR36 243
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ntf3 polyclonal IgG Rabbit
  • WB
Thermo Fisher Scientific (Lab Vision)
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations