Gene
kcnj1a.1
- ID
- ZDB-GENE-031118-55
- Name
- potassium inwardly rectifying channel subfamily J member 1a, tandem duplicate 1
- Symbol
- kcnj1a.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including gill; integument; ionocyte; pharyngeal arch; and pronephric duct. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63534 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Abbas et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bartter disease type 2 | Alliance | Bartter syndrome, type 2 | 241200 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
| Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
| Family | IPR003268 | FPotassium channel, inwardly rectifying, Kir1.1 |
| Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
| Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FPotassium channel, inwardly rectifying, Kir1.1 | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, transmembrane domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SY43 | InterPro | 370 | ||||||
| UniProtKB:Q1L8I4 | InterPro | 370 | ||||||
| UniProtKB:A0AB32TBQ6 | InterPro | 414 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnj1a.1-201
(1)
|
Ensembl | 1,816 nt | ||
| mRNA |
kcnj1a.1-202
(1)
|
Ensembl | 1,601 nt | ||
| mRNA |
kcnj1a.1-203
(1)
|
Ensembl | 1,634 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244H7 | ZFIN Curated Data | |
| Encodes | EST | fl37c05 | Abbas et al., 2011 | |
| Encodes | cDNA | MGC:63534 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201035 (1) | 1848 nt | ||
| Genomic | GenBank:BX927076 (1) | 152951 nt | ||
| Polypeptide | UniProtKB:A0AB32TBQ6 (1) | 414 aa |
- Wesselman, H.M., Gatz, A.E., Pfaff, M.R., Arceri, L., Wingert, R.A. (2023) Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 12(4):
- Park, J.S., Gabel, A.M., Kassir, P., Kang, L., Chowdhary, P.K., Osei-Ntansah, A., Tran, N.D., Viswanathan, S., Canales, B., Ding, P., Lee, Y.S., Brewster, R. (2022) N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. eLIFE. 11:
- Silic, M.R., Murata, S.H., Park, S.J., Zhang, G. (2021) Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(4):687-713
- Chambers, B.E., Clark, E.G., Gatz, A.E., Wingert, R.A. (2020) Kctd15 regulates nephron segment development by repressing Tfap2a activity. Development (Cambridge, England). 147(23):
- Chambers, B.E., Gerlach, G.F., Clark, E.G., Chen, K.H., Levesque, A.E., Leshchiner, I., Goessling, W., Wingert, R.A. (2019) Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development (Cambridge, England). 146(13):
- Sugano, Y., Lindenmeyer, M.T., Auberger, I., Ziegler, U., Segerer, S., Cohen, C.D., Neuhauss, S.C., Loffing, J. (2015) The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier. Kidney International. 88(5):1047-56
- Doupnik, C.A., Parra, K.C., Guida, W.C. (2014) A computational design approach for virtual screening of peptide interactions across K(+) channel families. Computational and structural biotechnology journal. 13:85-94
- Naylor, R.W., Przepiorski, A., Ren, Q., Yu, J., and Davidson, A.J. (2013) HNF1beta Is Essential for Nephron Segmentation during Nephrogenesis. Journal of the American Society of Nephrology : JASN. 24(1):77-87
- Abbas, L., Hajihashemi, S., Stead, L.F., Cooper, G.J., Ware, T.L., Munsey, T.S., Whitfield, T.T., and White, S.J. (2011) Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1. The Journal of physiology. 589(Pt 6):1489-503
- Hsiao, C.D., You, M.S., Guh, Y.J., Ma, M., Jiang, Y.J., and Hwang, P.P. (2007) A Positive Regulatory Loop between foxi3a and foxi3b Is Essential for Specification and Differentiation of Zebrafish Epidermal Ionocytes. PLoS One. 2(1):e302
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