Gene
hist2h2l
- ID
- ZDB-GENE-031118-36
- Name
- histone 2, H2, like
- Symbol
- hist2h2l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in chromatin. Is expressed in gill; heart; muscle; pleuroperitoneal region; and proliferative region. Orthologous to several human genes including H2BC17 (H2B clustered histone 17) and H2BC3 (H2B clustered histone 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73093 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa34932 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone-fold | Histone H2A/H2B/H3 | Histone H2B | Histone H2B, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q6PC60 | InterPro | 126 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hist2h2l-201
(1)
|
Ensembl | 824 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb1:hist2h2l-mCherry) |
|
| 1 | (3) | |
| Tg(actb2:hist2h2l-Citrine-AVI) |
|
| 1 | (2) | |
| Tg(EPV.Tp1-Mmu.Hbb:hist2h2l-mCherry) |
|
| 1 | (54) | |
| Tg(fabp10a:hist2h2l-mCherry) |
|
| 1 | Lee et al., 2023 | |
| Tg(Gga.Egr2:hist2h2l-mCherry) |
|
| 1 | (2) | |
| Tg(hist2h2l:GFP) |
|
| 1 | (3) | |
| Tg(kdrl:hist2h2l-EGFP) |
|
| 1 | (8) | |
| Tg(lyz:hist2h2l-mCherry) |
|
| 1 | (2) | |
| Tg(myo6b:hist2h2l-mScarletI) |
|
| 1 | Peloggia et al., 2021 | |
| Tg(Xla.Eef1a1:hist2h2l-mCherry) |
|
| 1 | (6) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-56I13 | ZFIN Curated Data | |
| Encodes | EST | cegs2546 | Rauch et al., 2003 | |
| Encodes | EST | fj05g08 | ||
| Encodes | cDNA | MGC:73093 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200117 (1) | 840 nt | ||
| Genomic | GenBank:BX120005 (2) | 129782 nt | ||
| Polypeptide | UniProtKB:Q6PC60 (1) | 126 aa |
No data available
- Lee, S., Memon, A., Chae, S.C., Shin, D., Choi, T.Y. (2024) Epcam regulates intrahepatic bile duct reconstruction in zebrafish, providing a potential model for primary cholangitis model. Biochemical and Biophysical Research Communications. 696:149512149512
- Giardoglou, P., Deloukas, P., Dedoussis, G., Beis, D. (2023) Cfdp1 Is Essential for Cardiac Development and Function. Cells. 12(15):
- Lee, S.H., So, J., Shin, D. (2023) Hepatocyte-to-cholangiocyte conversion occurs through transdifferentiation independently of proliferation in zebrafish. Hepatology (Baltimore, Md.). 77(4):1198-1210
- Leonard, E.V., Hasan, S.S., Siekmann, A.F. (2023) Temporally and regionally distinct morphogenetic processes govern zebrafish caudal fin blood vessel network expansion. Development (Cambridge, England). 150(7)
- Ma, J., Yang, Z., Huang, Z., Li, L., Huang, J., Chen, J., Ni, R., Luo, L., He, J. (2023) Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology (Baltimore, Md.). 78(1):167-178
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Rizvi, F., Lee, Y.R., Diaz-Aragon, R., Bawa, P.S., So, J., Florentino, R.M., Wu, S., Sarjoo, A., Truong, E., Smith, A.R., Wang, F., Everton, E., Ostrowska, A., Jung, K., Tam, Y., Muramatsu, H., Pardi, N., Weissman, D., Soto-Gutierrez, A., Shin, D., Gouon-Evans, V. (2023) VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis. Cell Stem Cell. 30(12):1640-1657.e8
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Karampelias, C., Watt, K., Mattsson, C.L., Ruiz, Á.F., Rezanejad, H., Mi, J., Liu, X., Chu, L., Locasale, J.W., Korbutt, G.S., Rovira, M., Larsson, O., Andersson, O. (2022) MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nature Chemical Biology. 18(9):942-953
- Leonard, E.V., Figueroa, R.J., Bussmann, J., Lawson, N.D., Amigo, J.D., Siekmann, A.F. (2022) Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signalling for their development. Development (Cambridge, England). 149(7)
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