Gene
slc25a37
- ID
- ZDB-GENE-031118-202
- Name
- solute carrier family 25 member 37
- Symbol
- slc25a37 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables iron ion transmembrane transporter activity. Acts upstream of or within embryonic hemopoiesis; erythrocyte maturation; and iron import into the mitochondrion. Located in mitochondrion. Is expressed in hematopoietic system; kidney; and lateral plate mesoderm. Orthologous to human SLC25A37 (solute carrier family 25 member 37).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b333 | Allele with one deletion | Unknown | Unknown | g-rays | |
| slc25a37_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| t23027 | Allele with one point mutation | Unknown | Missense | ENU | |
| tg221 | Allele with one point mutation | Unknown | Missense | ENU | |
| tg280a | Allele with one point mutation | Unknown | Missense | ENU | |
| tm130d | Allele with one point mutation | Unknown | Missense | ENU | |
| tq223 | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitochondrial carrier domain superfamily | Mitochondrial carrier protein | Mitochondrial substrate/solute carrier |
|---|---|---|---|---|---|
| UniProtKB:Q287T7 | InterPro | 332 | |||
| UniProtKB:B3DKD7 | InterPro | 332 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc25a37-201
(1)
|
Ensembl | 2,613 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(Mmu.Slc25a37:EGFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-200G12 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-417C7 | ZFIN Curated Data | |
| Encodes | EST | fc73c03 | ||
| Encodes | cDNA | MGC:195215 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195241 | ZFIN Curated Data | |
| Has Artifact | EST | fc73c08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039971 (1) | 5079 nt | ||
| Genomic | GenBank:CU694759 (2) | 33903 nt | ||
| Polypeptide | UniProtKB:B3DKD7 (1) | 332 aa |
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Germano, G., Porazzi, P., Felix, C. (2022) Leukemia-associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(10):1728-1740
- Rondelli, C.M., Perfetto, M., Danoff, A., Bergonia, H., Gillis, S., O'Neill, L., Jackson, L., Nicolas, G., Puy, H., West, R., Phillips, J.D., Yien, Y.Y. (2021) The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover. The Journal of biological chemistry. 297:100972
- Lawson, N.D., Li, R., Shin, M., Grosse, A., Yukselen, O., Stone, O.A., Kucukural, A., Zhu, L. (2020) An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. eLIFE. 9:
- Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Grillo, A.S., SantaMaria, A.M., Kafina, M.D., Cioffi, A.G., Huston, N.C., Han, M., Seo, Y.A., Yien, Y.Y., Nardone, C., Menon, A.V., Fan, J., Svoboda, D.C., Anderson, J.B., Hong, J.D., Nicolau, B.G., Subedi, K., Gewirth, A.A., Wessling-Resnick, M., Kim, J., Paw, B.H., Burke, M.D. (2017) Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science (New York, N.Y.). 356:608-616
- Davuluri, G., Song, P., Liu, Z., Wald, D., Sakaguchi, T.F., Green, M.R., Devireddy, L. (2016) Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 113(11):E1460-9
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