Gene

pknox2

ID

ZDB-GENE-031118-112

Name

pbx/knotted 1 homeobox 2

Symbol

pknox2 Nomenclature History

Previous Names

ft92g05
id:ibd2866
wu:ft92g05
zgc:136733

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in forebrain; immature eye; and midbrain. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu244 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pknox2 Human Ortholog

No data available

Associated With pknox2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001356	Homeodomain
Domain	IPR008422	KN homeodomain
Domain	IPR032453	Homeobox protein PKNOX/Meis, N-terminal
Family	IPR000990	Innexin
Family	IPR039099	Pannexin
Family	IPR050224	Three Amino acid Loop Extension (TALE) homeobox
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Homedomain-like superfamily	Homeobox protein PKNOX/Meis, N-terminal	Homeodomain	Innexin	KN homeodomain	Pannexin	Three Amino acid Loop Extension (TALE) homeobox
UniProtKB:Q8AYN1	InterPro	474
UniProtKB:A0A8M3B3A8	InterPro	921

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pknox2-201 (1) Ensembl	Ensembl	2,611 nt	Select Tool ZFIN BLAST
mRNA	pknox2-203 (1) Ensembl	Ensembl	3,682 nt	Select Tool ZFIN BLAST
mRNA	pknox2-204 (1) Ensembl	Ensembl	2,549 nt	Select Tool ZFIN BLAST
ncRNA	pknox2-002 (1) Ensembl	Ensembl	680 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations