Gene
dnaaf1
- ID
- ZDB-GENE-031114-4
- Name
- dynein axonemal assembly factor 1
- Symbol
- dnaaf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables dynein complex binding activity. Involved in cilium assembly. Acts upstream of or within several processes, including axoneme assembly; central canal development; and embryonic heart tube development. Predicted to be located in cilium. Predicted to be active in axoneme. Is expressed in several structures, including chordo neural hinge; forerunner cell group; intermediate mesoderm; nervous system; and pronephric duct. Used to study autosomal dominant polycystic kidney disease; idiopathic scoliosis; seminoma; and testicular germ cell cancer. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 13. Orthologous to human DNAAF1 (dynein axonemal assembly factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fk03a | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| hu255H | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20957 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40903 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tm317b | Allele with one point mutation | Unknown | Missense | not specified | |
| zf3430 | unknown | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dnaaf1 | Wang et al., 2020 | |
| CRISPR2-dnaaf1 | Wang et al., 2020 | |
| CRISPR3-dnaaf1 | Wang et al., 2020 | |
| CRISPR4-dnaaf1 | Wang et al., 2020 | |
| MO1-dnaaf1 | N/A | (2) |
| MO2-dnaaf1 | N/A | Colantonio et al., 2009 |
| MO3-dnaaf1 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 13 | Alliance | Ciliary dyskinesia, primary, 13 | 613193 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ciliary and flagellar integrity-associated protein | Leucine-rich repeat | Leucine-rich repeat domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:F1Q654 | InterPro | 562 | |||
| UniProtKB:Q7ZV84 | InterPro | 555 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
dnaaf1-202
(1)
|
Ensembl | 604 nt | ||
| mRNA |
dnaaf1-201
(1)
|
Ensembl | 2,594 nt | ||
| mRNA |
dnaaf1-203
(1)
|
Ensembl | 550 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-97H16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56169 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001319131 (1) | 1944 nt | ||
| Genomic | GenBank:CR376738 (2) | 118757 nt | ||
| Polypeptide | UniProtKB:F1Q654 (1) | 562 aa |
- Djebar, M., Anselme, I., Pezeron, G., Bardet, P.L., Cantaut-Belarif, Y., Eschstruth, A., López-Santos, D., Le Ribeuz, H., Jenett, A., Khoury, H., Veziers, J., Parmentier, C., Hirschler, A., Carapito, C., Bachmann-Gagescu, R., Schneider-Maunoury, S., Vesque, C. (2024) Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction. eLIFE. 13:
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Peng, L., Fu, W., Wu, X., He, S., Zhao, H., Liu, J., Liu, W., Xiao, Y. (2020) Bisexual Fertile Triploid Zebrafish (Danio rerio): a Rare Case. Marine biotechnology (New York, N.Y.). 22(3):443-455
- Thouvenin, O., Keiser, L., Cantaut-Belarif, Y., Carbo-Tano, M., Verweij, F., Jurisch-Yaksi, N., Bardet, P.L., van Niel, G., Gallaire, F., Wyart, C. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. 9:
- Wang, Y., Liu, Z., Yang, G., Gao, Q., Xiao, L., Li, J., Guo, C., Troutwine, B.R., Gray, R.S., Xie, L., Zhang, H. (2020) Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Frontiers in cell and developmental biology. 8:582255
- Whitfield, T.T. (2020) Cilia in the developing zebrafish ear. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 375:20190163
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Ferreira, R.R., Pakula, G., Klaeyle, L., Fukui, H., Vilfan, A., Supatto, W., Vermot, J. (2018) Chiral Cilia Orientation in the Left-Right Organizer. Cell Reports. 25:2008-2016.e4
- Juan, T., Géminard, C., Coutelis, J.B., Cerezo, D., Polès, S., Noselli, S., Fürthauer, M. (2018) Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. Nature communications. 9:1942
- Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
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