Gene
apc
- ID
- ZDB-GENE-031112-7
- Name
- APC regulator of WNT signaling pathway
- Symbol
- apc Nomenclature History
- Previous Names
-
- cb965 (1)
- im:7150932
- im:7152872
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to localize to several cellular components, including beta-catenin destruction complex; centrosome; and lateral plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Orthologous to human APC (APC regulator of WNT signaling pathway).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb965 (9 images)
- IMAGE:7150932 (8 images)
- IMAGE:7152872 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 67 figures from 27 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| familial adenomatous polyposis 1 | Alliance | Adenoma, periampullary, somatic | 175100 |
| familial adenomatous polyposis 1 | Alliance | Adenomatous polyposis coli | 175100 |
| familial adenomatous polyposis 1 | Alliance | Brain tumor-polyposis syndrome 2 | 175100 |
| familial adenomatous polyposis 1 | Alliance | Gardner syndrome | 175100 |
| hepatocellular carcinoma | Alliance | Hepatoblastoma, somatic | 114550 |
| hereditary desmoid disease | Alliance | Desmoid disease, hereditary | 135290 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
| Gastric adenocarcinoma and proximal polyposis of the stomach | 619182 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| familial adenomatous polyposis | apchu745/+; ia28Tg | standard conditions | Peron et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009232 | EB-1 binding |
| Domain | IPR009234 | Adenomatous polyposis coli protein basic domain |
| Domain | IPR032038 | Adenomatous polyposis coli, N-terminal dimerisation domain |
| Family | IPR026818 | Adenomatous polyposis coli (APC) family |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR026831 | Adenomatous polyposis coli protein |
| Homologous_superfamily | IPR036149 | APC, N-terminal coiled-coil domain superfamily |
| Repeat | IPR000225 | Armadillo |
| Repeat | IPR009223 | Adenomatous polyposis coli protein repeat |
| Repeat | IPR009224 | SAMP |
| Repeat | IPR009240 | Adenomatous polyposis coli protein, 15 residue repeat |
| Repeat | IPR041257 | Adenomatous polyposis coli (APC) repeat |
Domain Details Per Protein
| Protein | Length | Adenomatous polyposis coli (APC) family | Adenomatous polyposis coli (APC) repeat | Adenomatous polyposis coli, N-terminal dimerisation domain | Adenomatous polyposis coli protein | Adenomatous polyposis coli protein, 15 residue repeat | Adenomatous polyposis coli protein basic domain | Adenomatous polyposis coli protein repeat | APC, N-terminal coiled-coil domain superfamily | Armadillo | Armadillo-like helical | Armadillo-type fold | EB-1 binding | SAMP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IWH7
|
2754 | |||||||||||||
|
UniProtKB:A0A8M2B1L0
|
2745 |
Interactions and Pathways
No data available
Plasmids
No data available