ZFIN is now using GRCz12tu for Genomic Data
Gene
flnba
- ID
- ZDB-GENE-031112-6
- Name
- filamin B a
- Symbol
- flnba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable actin filament binding activity. Predicted to act upstream of or within actin cytoskeleton organization. Is expressed in several structures, including nervous system; otic vesicle; pectoral fin; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B).
- Genome Resources
- Note
-
Represented by two gene models in Ensembl GRCz11
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb967 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| atelosteogenesis | Alliance | Atelosteogenesis, type I | 108720 |
| atelosteogenesis | Alliance | Atelosteogenesis, type III | 108721 |
| Boomerang dysplasia | Alliance | Boomerang dysplasia | 112310 |
| Larsen syndrome | Alliance | Larsen syndrome | 150250 |
| spondylocarpotarsal synostosis syndrome | Alliance | Spondylocarpotarsal synostosis syndrome | 272460 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M6Z8T4 | InterPro | 2592 |
| UniProtKB:A0A8M9QDU6 | InterPro | 2564 |
| UniProtKB:A0AC58GU10 | InterPro | 2592 |
| UniProtKB:A0AC58GU30 | InterPro | 2564 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers